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Course Description Course Name : Cell biophysics-1 Course Code : BFZ-540 Course Type : Optional Level of Course : Second Cycle Year of Study : 1 Course Semester : Fall (16 Weeks) ECTS : 6 Name of Lecturer(s) : Prof.Dr. İSMAİL GÜNAY Learning Outcomes of the Course : comprehends the importance of molecular bonding learns the molecular transport of the particle through the membrane discusses the generation mechanism of resting membrane potential Knows the blocking mechanism of ion channel blockers Discusses the strengths of intracellular recording methods Learns the relation between the patch-clam method and channel conductance Mode of Delivery : Face-to-Face Prerequisites and Co-Prerequisites : None Recommended Optional Programme Components : None Aim(s) of Course : Analyzing bioelectrical and biomehanical events in a cell with biophysical methods Course Contents : Structure of atoms, molecular bonding and forces, diffusion, osmosis, structure of cell membrane, transport through cell membrane, generation mechanism of resting membrane potential, Nernst´s equation, GHK equation an steady state, ion channels, channel blockers, microelectrode, voltage-clamp and patch clamp methods Language of Instruction : Turkish Work Place : Classroom, laboratuary   Course Outline /Schedule (Weekly) Planned Learning Activities Week Subject Student's Preliminary Work Learning Activities and Teaching Methods 1 The Structure of atom related reading lecture, sample analysis, question and answer,disussion 2 Intermolecular forces and bonding related reading lecture, sample analysis, question and answer,disussion 3 Diffusion and osmos related reading lecture, sample analysis, question and answer,disussion 4 Cell membrane structure and function related reading lecture, sample analysis, question and answer,disussion 5 Particle transport through cell membrane related reading lecture, sample analysis, question and answer,disussion 6 generation mechanism of resting membrane potential and Nernst´s equation related reading lecture, sample analysis, question and answer,disussion 7 GHK equation and persistent state related reading lecture, sample analysis, question and answer,disussion 8 ion channels related reading lecture, sample analysis, question and answer,disussion 9 channel blockers related reading lecture, sample analysis, question and answer,disussion 10 microelectrode recording methods related reading lecture, sample analysis, question and answer,disussion 11 voltage-clamp and patch clamp methods related reading lecture, sample analysis, question and answer,disussion 12 Homework2 Textbook and literature review Face to face discussion 13 the relation between ion concentration and membrane potential Textbook and literature review Face to face discussion 14 Hodgkin-huxley membrane model Textbook and literature review Face to face discussion 15 Homework3 Textbook and literature review Face to face discussion 16/17 Final exam oral and written exam   Required Course Resources Resource Type Resource Name Recommended Course Material(s)           Required Course Material(s)   Assessment Methods and Assessment Criteria Semester/Year Assessments Number Contribution Percentage     Mid-term Exams (Written, Oral, etc.) 1 60     Homeworks/Projects/Others 3 40 Total 100 Rate of Semester/Year Assessments to Success 40   Final Assessments 100 Rate of Final Assessments to Success 60 Total 100   Contribution of the Course to Key Learning Outcomes # Key Learning Outcome Contribution* 1 Students do an experiment on their own 1 2 Students have analytic notion mechanism related to the field, they are able to have access to reliable knowledge, they are able to design and write a research project , they study depending on ethical values 3 3 Students are able to systematically impart the theoretical knowledge that is being investigated to the audience effectively and transfer it to public 3 4 Students are able to report the results of a research 3 5 Students are able to interpret the findings of a research 3 6 Students have scientific consideration related to the profession 4 7 Students do an experimental setup in the laboratory and study on it 4 8 Students plan an experimental research 2 9 Students get basic knowledge of the specialiity 5 10 Students prepare a project proposal by themselves 2 * Contribution levels are between 0 (not) and 5 (maximum).   Student Workload - ECTS Works Number Time (Hour) Total Workload (Hour) Course Related Works     Class Time (Exam weeks are excluded) 14 2 28     Out of Class Study (Preliminary Work, Practice) 14 4 56 Assesment Related Works     Homeworks, Projects, Others 3 15 45     Mid-term Exams (Written, Oral, etc.) 1 5 5     Final Exam 1 5 5 Total Workload: 139 Total Workload / 25 (h): 5.56 ECTS Credit: 6