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| Course Description |
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| Course Name |
: |
Enzymes And Enzyme Kinetics |
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| Course Code |
: |
KM 478 |
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| Course Type |
: |
Optional |
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| Level of Course |
: |
First Cycle |
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| Year of Study |
: |
4 |
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| Course Semester |
: |
Spring (16 Weeks) |
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| ECTS |
: |
4 |
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| Name of Lecturer(s) |
: |
Prof.Dr. SEYHAN TÜKEL
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| Learning Outcomes of the Course |
: |
learn fundamental principles of enzyme kinetics, enzyme inhibition and activation and enzymatic regulation
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| Mode of Delivery |
: |
Face-to-Face |
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| Prerequisites and Co-Prerequisites |
: |
None |
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| Recommended Optional Programme Components |
: |
None |
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| Aim(s) of Course |
: |
To learn fundamental principles of enzyme kinetics |
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| Course Contents |
: |
Enzyme Structure, Enzyme Kinetics, Steady-State Kinetics and the Michaelis-Menten Equation, Analysis of Enzyme Kinetic Data, Reversible Enzyme Reactions, Enzyme Inhibition
Multi-Substrate Reactions, Derivation of Rate Equations of Complex Enzyme Mechanisms, Kinetics of Allosteric Enzymes, Special Enzyme Mechanisms, pH and Temperature Dependence of Enzymes, Application of Statistical Methods in Enzyme Kinetics.
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| Language of Instruction |
: |
Turkish |
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| Work Place |
: |
Classroom |
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Course Outline /Schedule (Weekly) Planned Learning Activities |
| Week | Subject | Student's Preliminary Work | Learning Activities and Teaching Methods |
|
1 |
Enzyme Structure
|
Enzyme kinetics books, lecture notes |
Lecture course |
|
2 |
Enzyme Kinetics |
Enzyme kinetics books, lecture notes |
Lecture course |
|
3 |
Steady-State Kinetics and the Michaelis-Menten Equation |
Enzyme kinetics books, lecture notes |
Lecture course |
|
4 |
Analysis of Enzyme Kinetic Data |
Enzyme kinetics books, lecture notes |
Lecture course |
|
5 |
Reversible Enzyme Reactions
|
Enzyme kinetics books, lecture notes |
Lecture course |
|
6 |
Enzyme Inhibition |
Enzyme kinetics books, lecture notes |
Lecture course |
|
7 |
Multi-Substrate Reactions |
Enzyme kinetics books, lecture notes |
Lecture course |
|
8 |
Midterm exam |
Enzyme kinetics books, lecture notes |
Exam |
|
9 |
Derivation of Rate Equations of Complex Enzyme
Mechanisms
|
Enzyme kinetics books, lecture notes |
Lecture course |
|
10 |
Kinetics of Allosteric Enzymes |
Enzyme kinetics books, lecture notes |
Lecture course |
|
11 |
Special Enzyme Mechanisms |
Enzyme kinetics books, lecture notes |
Lecture course |
|
12 |
pH and Temperature Dependence of Enzymes |
Enzyme kinetics books, lecture notes |
Lecture course |
|
13 |
Application of Statistical Methods in Enzyme Kinetics
|
Enzyme kinetics books, lecture notes |
Lecture course |
|
14 |
Project |
Enzyme kinetics books, lecture notes |
Lecture course |
|
15 |
Project |
Enzyme kinetics books, lecture notes |
Lecture course |
|
16/17 |
Final Exam |
Enzyme kinetics books, lecture notes |
Exam |
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Required Course Resources |
| Resource Type | Resource Name |
| Recommended Course Material(s) |
 Hans Bisswanger, Enzyme Kinetics Principles and Methods, 2002 WILEY-VCH Verlag GmbH, Weinheim
Vladimir Leskovac, Comprehensive Enzyme Kinetics, 2003, Kluwer Academic/ Plenum Publishers
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| |
| Required Course Material(s) | |
|
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Assessment Methods and Assessment Criteria |
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Semester/Year Assessments |
Number |
Contribution Percentage |
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Mid-term Exams (Written, Oral, etc.) |
1 |
60 |
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Homeworks/Projects/Others |
1 |
40 |
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Total |
100 |
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Rate of Semester/Year Assessments to Success |
40 |
| |
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Final Assessments
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100 |
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Rate of Final Assessments to Success
|
60 |
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Total |
100 |
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| Contribution of the Course to Key Learning Outcomes |
| # | Key Learning Outcome | Contribution* |
|
1 |
Feel comfortable with chemistry knowledge and capable to make relation with practical applicaitons |
4 |
|
2 |
Observe and analyze the developments, directions and needs of industires for sustainability |
2 |
|
3 |
Acquire life long education capability |
2 |
|
4 |
Have capability of reaching for information |
3 |
|
5 |
Acknowledge about total quality and relating the knowledge from different disciplines |
3 |
|
6 |
Have capability of evaluating the national sources for technology development |
2 |
|
7 |
Have capability of transmitting the knowledge and relating different disciplines |
4 |
|
8 |
Gain the ability to achieve new knowledge and technology |
4 |
|
9 |
Learn problem solving methodolygy and creative thinking |
3 |
|
10 |
Have capability of bringing together theory and practical applicaiton |
3 |
|
11 |
Feel comfortable with laboratory studies |
1 |
|
12 |
Follow the developments in chemistry industries |
3 |
|
13 |
Monitor progress in the field of chemistry. |
3 |
|
14 |
Have capability of team work and leadership |
2 |
|
15 |
Acquire property of objective and critical view |
2 |
| * Contribution levels are between 0 (not) and 5 (maximum). |
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| Student Workload - ECTS |
| Works | Number | Time (Hour) | Total Workload (Hour) |
| Course Related Works |
|
Class Time (Exam weeks are excluded) |
14 |
3 |
42 |
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Out of Class Study (Preliminary Work, Practice) |
14 |
3 |
42 |
| Assesment Related Works |
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Homeworks, Projects, Others |
1 |
4 |
4 |
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Mid-term Exams (Written, Oral, etc.) |
1 |
6 |
6 |
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Final Exam |
1 |
6 |
6 |
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Total Workload: | 100 |
| Total Workload / 25 (h): | 4 |
| ECTS Credit: | 4 |
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