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Course Description Course Name : Bone Mrrow Immunology and Laboratory I Course Code : PH-560 Course Type : Optional Level of Course : Second Cycle Year of Study : 1 Course Semester : Fall and Spring (16 Weeks) ECTS : 5 Name of Lecturer(s) : Prof.Dr. YURDANUR KILINÇ Learning Outcomes of the Course : A sudent learns and performs the immunologies of peripheral blood and bone marrow cells. A sudent can perform simple tests related to the immunologies of peripheral blood and bone marrow cells. Mode of Delivery : Face-to-Face Prerequisites and Co-Prerequisites : None Recommended Optional Programme Components : None Aim(s) of Course : After completion of "bone marrow immunology and Laboratory"course, students will learn and perform practices about determination of HLA-human lymphocyte antigens and cell culture. Course Contents : HLA tissue group antigens, serological methods, PCR method; general knowledge about cell culture, preparation of cell culture mediums and breeding, bone marrow culture for long period, preparation of equipment for cell culture. Language of Instruction : Turkish Work Place : Pediatric Hematology Seminar halls and Laboratories.   Course Outline /Schedule (Weekly) Planned Learning Activities Week Subject Student's Preliminary Work Learning Activities and Teaching Methods 1 The Structure of Bone Marrow Practice and Laboratory Work Study from the sources given before, literature search Instruction, seminar, group discussion, brain storming. 2 The Specialties of Peripheral Blood C Practice and Laboratoory Work Study from the sources given before, literature search Instruction, seminar, group discussion, brain storming. 3 The Functions of Peripheral Blood Cells(mononuclear, polymorphonuclear) Practice and laboratory Work Study from the sources given before, literature search Instruction, seminar, group discussion, brain storming. 4 Lymphatic System:Development of Immune System, Practice and Laboratory Work. Study from the sources given before, literature search Instruction, seminar, group discussion, brain storming. 5 Phagocytic and Immune System Practice and Laboratory Work Study from the sources given before, literature search Instruction, seminar, group discussion, brain storming. 6 Complement System and Working Profile Practice and Laboratory Work Study from the sources given before, literature search Instruction, seminar, group discussion, brain storming. 7 The Interactions between the Cells in Immune Response Practice and Laboratory Work Study from the sources given before, literature search Instruction, seminar, group discussion, brain storming. 8 Practice and Laboratory Work Study from the sources given before, literature search Instruction, seminar, group discussion, brain storming. 9 The Phenotyping of Bone Marrow Stem Cells Practice and Laboratory Work Study from the sources given before, literature search Instruction, seminar, group discussion, brain storming. 10 The Mobiliaation of the Bone marrow Stem Cells. Practice and Laboratory Work Study from the sources given before, literature search Instruction, seminar, group discussion, brain storming. 11 The Characterization of Bone Marrow Stem Cells Practice and Laboratory Work Study from the sources given before, literature search Instruction, seminar, group discussion, brain storming. 12 The Role of Cytokines in Stem Cell Mobilisation Practice and Laboratory Work Study from the sources given before, literature search Instruction, seminar, group discussion, brain storming. 13 The Collection and Processing of Hematopoietic Stem Cells. Practice and Laboratory Work Study from the sources given before, literature search Instruction, seminar, group discussion, brain storming. 14 Seminar Study from the sources given before, literature search Instruction, seminar, group discussion, brain storming. 15 Make-up Lesson Practice and Laboratory Work Study from the sources given before, literature search Instruction, seminar, group discussion, brain storming. 16/17 Final Exam Revision of the sources Written/oral or applied exams   Required Course Resources Resource Type Resource Name Recommended Course Material(s)  Molecular Hematology:Provan D,and Gribben J(eds), Blackwell Scientific Co, Tokyo, 2000  Hematology of Infancy and Childhood:Nathan DG, Oski FA(eds), 4th ed, WB Saunders Company, Philadelphia, 1993 Required Course Material(s)   Assessment Methods and Assessment Criteria Semester/Year Assessments Number Contribution Percentage     Mid-term Exams (Written, Oral, etc.) 1 90     Homeworks/Projects/Others 2 10 Total 100 Rate of Semester/Year Assessments to Success 40   Final Assessments 100 Rate of Final Assessments to Success 60 Total 100   Contribution of the Course to Key Learning Outcomes # Key Learning Outcome Contribution* 1 A student can perform laboratory techniques. 4 2 A student can communicate and create bonds with the patients. 1 3 A student can teach the bone marrow stromal and medullary componants which are basic components of hematology. 4 4 A student can describe the rules of basic hematology. 3 5 A student can become trained in the area of molecular changes in benign and malign hematological disorders. 4 6 A students acknowledges blood cells biologies, blood and blood components transfusion and stem cell transplantation procedures. 3 7 A student gets prepared for stem cell transplant, collection, seperation, freezing topics. 4 8 A student can explain the structure and functions of erythrocytes, leucocytes and platelets. 1 9 A student can work in a pediatric hematology laboratory. 4 10 A student gets prepared for basic rules of gene therapy. 4 11 A student can investigate the molecular basis of benign and malign hematological disorders. 3 12 A student can explain the physiopathologies and results of hemostasis and thrombosis. 4 13 A student becomes competent in the application areas of blood cells and components and bone marrow transplantation 4 14 A student can perform application of the laboratory techniques necessary for pediatric hematology. 5 * Contribution levels are between 0 (not) and 5 (maximum).   Student Workload - ECTS Works Number Time (Hour) Total Workload (Hour) Course Related Works     Class Time (Exam weeks are excluded) 14 4 56     Out of Class Study (Preliminary Work, Practice) 14 1 14 Assesment Related Works     Homeworks, Projects, Others 2 20 40     Mid-term Exams (Written, Oral, etc.) 1 10 10     Final Exam 1 10 10 Total Workload: 130 Total Workload / 25 (h): 5.2 ECTS Credit: 5