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Course Description Course Name : The Processing of Bone Marrow I Course Code : PH-540 Course Type : Optional Level of Course : Second Cycle Year of Study : 1 Course Semester : Fall and Spring (16 Weeks) ECTS : 5 Name of Lecturer(s) : Prof.Dr. YURDANUR KILINÇ Learning Outcomes of the Course : A student learns and perform how to aspirate bone marrow specimen. A student learns the techniques of smear, staining, collection of cells, seperation and freezing. Mode of Delivery : Face-to-Face Prerequisites and Co-Prerequisites : None Recommended Optional Programme Components : None Aim(s) of Course : When students complete the "bone marrow processing "course, they will learn and perform applications of the selection of bone marrow cells, earch for tumor cells, and T cell depletion processing. Course Contents : In vitro methods for bone marrow transplantation, cell seperation, searching for metastatic tumor cells , entrance to the bone marrow transplantation and methods, quality control in processes of bone marrow, product collection and reinfusion, flow-cytometric analysis, dose modification of lymphocytes, T cell depletion of allogeneic bone marrow grafts, CD5+ T cell depletion from bone marrow cells for GVHD prophylaxis. Language of Instruction : Turkish Work Place : The Seminar Halls and Laboratories of Pediatric Hematology, Blood Bank Unit and Pediatric BMT Laboratories.   Course Outline /Schedule (Weekly) Planned Learning Activities Week Subject Student's Preliminary Work Learning Activities and Teaching Methods 1 Sterilization Practice Laboratory Work Preparation from the sources given Instruction, group discussion, seminar, brain storming 2 Dysinfection Practice and Laboratory Work Preparation from the sources given Instruction, group discussion, seminar, brain storming 3 Practice and Laboratory Work Preparation from the sources given Instruction, group discussion, seminar, brain storming 4 Determination of Quantitation and Evaluation Practica and Laboratory Work Preparation from the sources given Instruction, group discussion, seminar, brain storming 5 Practice and Laboratory Work Preparation from the sources given Instruction, group discussion, seminar, brain storming 6 Contamination Practice and Laboratory Work Preparation from the sources given Instruction, group discussion, seminar, brain storming 7 Practice and Laboratory Work Preparation from the sources given Instruction, group discussion, seminar, brain storming 8 Erythrocyte, plasma and T-Cell Depletion . Practice and Laboratory Work Preparation from the sources given Instruction, group discussion, seminar, brain storming 9 Practice and Laboratory Work Preparation from the sources given Instruction, group discussion, seminar, brain storming 10 Preservation of Stem Cells Practice and Laboratory Work Preparation from the sources given Instruction, group discussion, seminar, brain storming 11 Practice and Laboratory Work Preparation from the sources given Instruction, group discussion, seminar, brain storming 12 Purging: Practice and Laboratory Work Preparation from the sources given Instruction, group discussion, seminar, brain storming 13 Seminar Preparation from the sources given Instruction, group discussion, seminar, brain storming 14 Practice and Laboratory Work Preparation from the sources given Instruction, group discussion, seminar, brain storming 15 Practice and Laboratory Work Preparation from the sources given Instruction, group discussion, seminar, brain storming 16/17 Final Examination Revision from the sources given Written/oral or applied exams   Required Course Resources Resource Type Resource Name Recommended Course Material(s)  Hematopoietic Stem Cell transplantation:Apperley J, Carreras E, Gluckman E, Gratwohl A, Masszi T(eds), The European School of Hematology EBMT Handbook, 5t ed, Saint Louis, 2008. Required Course Material(s)   Assessment Methods and Assessment Criteria Semester/Year Assessments Number Contribution Percentage     Mid-term Exams (Written, Oral, etc.) 1 90     Homeworks/Projects/Others 2 10 Total 100 Rate of Semester/Year Assessments to Success 40   Final Assessments 100 Rate of Final Assessments to Success 60 Total 100   Contribution of the Course to Key Learning Outcomes # Key Learning Outcome Contribution* 1 A student can perform laboratory techniques. 4 2 A student can communicate and create bonds with the patients. 1 3 A student can teach the bone marrow stromal and medullary componants which are basic components of hematology. 4 4 A student can describe the rules of basic hematology. 4 5 A student can become trained in the area of molecular changes in benign and malign hematological disorders. 4 6 A students acknowledges blood cells biologies, blood and blood components transfusion and stem cell transplantation procedures. 4 7 A student gets prepared for stem cell transplant, collection, seperation, freezing topics. 4 8 A student can explain the structure and functions of erythrocytes, leucocytes and platelets. 4 9 A student can work in a pediatric hematology laboratory. 4 10 A student gets prepared for basic rules of gene therapy. 2 11 A student can investigate the molecular basis of benign and malign hematological disorders. 4 12 A student can explain the physiopathologies and results of hemostasis and thrombosis. 3 13 A student becomes competent in the application areas of blood cells and components and bone marrow transplantation 4 14 A student can perform application of the laboratory techniques necessary for pediatric hematology. 3 * Contribution levels are between 0 (not) and 5 (maximum).   Student Workload - ECTS Works Number Time (Hour) Total Workload (Hour) Course Related Works     Class Time (Exam weeks are excluded) 14 4 56     Out of Class Study (Preliminary Work, Practice) 14 1 14 Assesment Related Works     Homeworks, Projects, Others 2 20 40     Mid-term Exams (Written, Oral, etc.) 1 10 10     Final Exam 1 10 10 Total Workload: 130 Total Workload / 25 (h): 5.2 ECTS Credit: 5