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Course Description Course Name : Entrance to the Basic Hematology Course Code : PH-500 Course Type : Compulsory Level of Course : Sub-Level (Undergraduate Degree) Year of Study : 1 Course Semester : Fall (16 Weeks) ECTS : 5 Name of Lecturer(s) : Prof.Dr. YURDANUR KILINÇ Prof.Dr. HATİCE İLGEN ŞAŞMAZ Prof.Dr. BİROL GÜVENÇ Learning Outcomes of the Course : A student can operate peripheral blood smear and staining techniques, bone marrow smear and staining techniques, special staining techniques and can evaluate the results. A student can perform CBC and reitcs counts. Mode of Delivery : Face-to-Face Prerequisites and Co-Prerequisites : PH-500 Entrance to the Basic Hematology Recommended Optional Programme Components : None Aim(s) of Course : When students finish PH-500 Course, they will gain the knowledge about blood cells, liquid phase of the blood, the differentation of stem cells from bone marrow red blood cells, leucocytes, platelets.They will also learn which patophysiological changes effect the laboratory tests and they will learn to differ pathological cases from normal ;they will use laboratory tools and they will have command on possible issues. Course Contents : The principles of hematological examination, bone marrow development and differentiation of bone marrow cells, red blood cells, white blood cells, platelets, the structure and synthesis of hemoglobin, iron metabolism, hemoglobin disorders and laboratory diagnosis, the thalassemias and laboratory dianosis, erythrocytic enzymopathies and laboratory diagnosis, platelets, Vitamine B12 metabolism , the laboratory diagnosis of Vitamin B12 deficiency, folate metabolism, the laboratory diagnosis of folate deficiency. Language of Instruction : Turkish Work Place : The Seminar Halls and laboratories of Pediatric Hematology Department .   Course Outline /Schedule (Weekly) Planned Learning Activities Week Subject Student's Preliminary Work Learning Activities and Teaching Methods 1 The principles of hematological evaluation Practice and Laboratory work Reading the sources,seminar, practice Instruction, presentation, group discussion, brainstorming, seminar, exercise 2 The reproduction and differentiation of cells Practice and Laboratory work Reading the sources,seminar, practice Instruction, presentation, group discussion, brainstorming, seminar, exercise 3 The blood production in embrio, fetus, and newborn Practice and Laboratory work Reading the sources,seminar, practice Instruction, presentation, group discussion, brainstorming, seminar, exercise 4 Bone marrow:Obtaining the sample, staining, special staining technics. Practice and Laboratory Work Reading the sources,seminar, practice Instruction, presentation, group discussion, brainstorming, seminar, exercise 5 Erythrocyte and Laboratory Evaluation Practice and Laboratory Work Reading the sources,seminar, practice Instruction, presentation, group discussion, brainstorming, seminar, exercise 6 Iron metabolism, Structure and Synthesis of Hemoglobin Practice and Laboratory Work Reading the sources,seminar, practice Instruction, presentation, group discussion, brainstorming, seminar, exercise 7 Erythrocyte aging, Mechanism and Sites of Destruction , Catabolism of Hemoglobin Practice and Laboratory Work Reading the sources,seminar, practice Instruction, presentation, group discussion, brainstorming, seminar, exercise 8 Granulocytes and Monocytes;morphology and chemical properties. Practice and Laboratory Work Reading the sources,seminar, practice Instruction, presentation, group discussion, brainstorming, seminar, exercise 9 Lymphatic System, the evolution of immune system, investigation methods of Complement System Practice and Laboratory Work Reading the sources,seminar, practice Instruction, presentation, group discussion, brainstorming, seminar, exercise 10 Platelets and Megakaryocytes;Development of Primary Hemostasis Practice and Laboratory Work Reading the sources,seminar, practice Instruction, presentation, group discussion, brainstorming, seminar, exercise 11 Coagulation Factors, Coagulation Physiology Practice and Laboratory Work Reading the sources,seminar, practice Instruction, presentation, group discussion, brainstorming, seminar, exercise 12 Fibrinolytic System Practise Laboratory Work Reading the sources,seminar, practice Instruction, presentation, group discussion, brainstorming, seminar, exercise 13 Blood Groups, Typing Practiise and Laboratory Work Reading the sources,seminar, practice Instruction, presentation, group discussion, brainstorming, seminar, exercise 14 HLA Human Lymphocyte Antigentissue Groups Practice and Laboratory Work Reading the sources,seminar, practice Instruction, presentation, group discussion, brainstorming, seminar, exercise 15 Semiannual Seminar Reading the sources,seminar, practice, literature screening and searching Instruction, presentation, group discussion, brainstorming, seminar, exercise 16/17 Final Exam Revising the sources, lecture notes and other literature on the topics covered. Written and oral exams   Required Course Resources Resource Type Resource Name Recommended Course Material(s)  Hematology:Clinical and Laboratory Practice. Bick RL, Vol 1 ve 2, CV Mosby Company, St. Louise, 1993.  Clinical Hematology:Theory and Procedures. Turgeon ML, 4th ed, Lippincott Wlliams and Wilkins, 2005  Wintrobe’s Clinical Hematology:Greer JP, Foerster J, Lukens JN, Rodgers GM, Paraskaras F, Glader B(eds), Vol 1 and 2, 11th ed, Lippincott Williams and Wilkins, Philadelphia, 2004.  Hematology of Infancy and Childhood:Nathan DG, Oski FA(eds), 4th ed, WB Saunders Company, Philadelphia, 1993. Required Course Material(s)   Assessment Methods and Assessment Criteria Semester/Year Assessments Number Contribution Percentage     Mid-term Exams (Written, Oral, etc.) 1 90     Homeworks/Projects/Others 2 10 Total 100 Rate of Semester/Year Assessments to Success 40   Final Assessments 100 Rate of Final Assessments to Success 60 Total 100   Contribution of the Course to Key Learning Outcomes # Key Learning Outcome Contribution* 1 A student can perform laboratory techniques. 5 2 A student can communicate and create bonds with the patients. 5 3 A student can teach the bone marrow stromal and medullary componants which are basic components of hematology. 4 4 A student can describe the rules of basic hematology. 5 5 A student can become trained in the area of molecular changes in benign and malign hematological disorders. 3 6 A students acknowledges blood cells biologies, blood and blood components transfusion and stem cell transplantation procedures. 4 7 A student gets prepared for stem cell transplant, collection, seperation, freezing topics. 5 8 A student can explain the structure and functions of erythrocytes, leucocytes and platelets. 5 9 A student can work in a pediatric hematology laboratory. 5 10 A student gets prepared for basic rules of gene therapy. 4 11 A student can investigate the molecular basis of benign and malign hematological disorders. 4 12 A student can explain the physiopathologies and results of hemostasis and thrombosis. 5 13 A student becomes competent in the application areas of blood cells and components and bone marrow transplantation 3 14 A student can perform application of the laboratory techniques necessary for pediatric hematology. 5 * Contribution levels are between 0 (not) and 5 (maximum).   Student Workload - ECTS Works Number Time (Hour) Total Workload (Hour) Course Related Works     Class Time (Exam weeks are excluded) 14 4 56     Out of Class Study (Preliminary Work, Practice) 14 1 14 Assesment Related Works     Homeworks, Projects, Others 2 20 40     Mid-term Exams (Written, Oral, etc.) 1 10 10     Final Exam 1 10 10 Total Workload: 130 Total Workload / 25 (h): 5.2 ECTS Credit: 5