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Course Description Course Name : Biochemical Toxicology Course Code : BL 442 Course Type : Optional Level of Course : First Cycle Year of Study : 4 Course Semester : Spring (16 Weeks) ECTS : 4 Name of Lecturer(s) : Prof.Dr. ELİF ORUÇ Learning Outcomes of the Course : Know general principles of toxicology Learn toxic effect mechanisms of xenobiotics have detail information about cell damage and protective mechanisms Mode of Delivery : Face-to-Face Prerequisites and Co-Prerequisites : None Recommended Optional Programme Components : None Aim(s) of Course : The aim of this course is to provıde knowledge and understanding about the principles of toxicology, xenobiotic metabolism. Also it will be discussed on cell damage together with biochemical and molecular toxicity mechanisms of xenobiotics. Course Contents : Principles of toxicology, toxic effect mechanisms of xenobiotics, cell damage and protective mechanisms Language of Instruction : Turkish Work Place : Class   Course Outline /Schedule (Weekly) Planned Learning Activities Week Subject Student's Preliminary Work Learning Activities and Teaching Methods 1 Introduction to biochemical toxicology Review of the relevant pages from sources Lecture and discussion 2 Absorption, distribution, metabolism, side of action and excretion Review of the relevant pages from sources Lecture and discussion 3 Molecular techniques in toxicology Review of the relevant pages from sources Lecture and discussion 4 Phase I metabolism and pharmacogenetic Review of the relevant pages from sources Lecture and discussion 5 Conjugation and elimination of toxic substances Review of the relevant pages from sources Lecture and discussion 6 Physiological factors affecting xenobiotic metabolism Review of the relevant pages from sources Lecture and discussion 7 Adaptation to toxicants Review of the relevant pages from sources Lecture and discussion 8 Mid-term exam Mid-term exam Mid-term exam 9 Cell injury and cellular protection mechanism Review of the relevant pages from sources Lecture and discussion 10 Reactive metabolites and toxicity Review of the relevant pages from sources Lecture and discussion 11 Central nervous system Review of the relevant pages from sources Lecture and discussion 12 Neurodegenerative disseas neurotoxicity mechanisms Review of the relevant pages from sources Lecture and discussion 13 Hepatotoxicity Review of the relevant pages from sources Lecture and discussion 14 Nutritinal Factors Review of the relevant pages from sources Lecture and discussion 15 Reproductive toxicology Review of the relevant pages from sources Lecture and discussion 16/17 Final exam Final exam Final exam   Required Course Resources Resource Type Resource Name Recommended Course Material(s)  Hodgson, E., Smart, R.C. (2001), Introduction to Biochemical Toxicology,John Wiley and Sons, New York, 721 pp. Required Course Material(s)   Assessment Methods and Assessment Criteria Semester/Year Assessments Number Contribution Percentage     Mid-term Exams (Written, Oral, etc.) 1 60     Homeworks/Projects/Others 1 40 Total 100 Rate of Semester/Year Assessments to Success 40   Final Assessments 100 Rate of Final Assessments to Success 60 Total 100   Contribution of the Course to Key Learning Outcomes # Key Learning Outcome Contribution* 1 Explains the methods of producing scientific knowledge in the field of biology 4 2 Uses the advanced theoretical and practical knowledge acquired in the field of biology 3 3 Develops his/her professional experiences and knowledges by taking elective courses together with basic subjects of biology 0 4 takes responsibility as an individual or in a group to solve unpredicted problems that would be encountered 3 5 plans and manages the projects as a member of team 4 6 informs an indivudual and institutions about the subjects related to biology, and prepare verbal and written presentation to solve the problems 5 7 communicates effectively with colleagues in the world about biological issues and works 0 8 Knows the importance of individual development 4 9 Reaches the Information in the field of physics, for the purpose of classification, and uses. 4 10 Knows that learning process is life-long and acts accordingly. 5 11 Evaluates the developmets in the field of biology by using scientific methods 4 12 Explains the basic concepts and principles in the field of biology 5 13 Combines the knowledge in the field of biology with the other scientific area. 4 14 Both with colleagues, as well as off the field of builds establish relations ethically and uses information, communication technologies. Defines necessities in learning in scientific, social, cultural and artistic areas and improves himself/herself accordingly. 4 15 Identifies problems in the field of biology and for the solutions apply the analytical and simulative methods. 2 * Contribution levels are between 0 (not) and 5 (maximum).   Student Workload - ECTS Works Number Time (Hour) Total Workload (Hour) Course Related Works     Class Time (Exam weeks are excluded) 14 2 28     Out of Class Study (Preliminary Work, Practice) 14 2 28 Assesment Related Works     Homeworks, Projects, Others 1 10 10     Mid-term Exams (Written, Oral, etc.) 1 10 10     Final Exam 1 20 20 Total Workload: 96 Total Workload / 25 (h): 3.84 ECTS Credit: 4