| Course Description |
|
| Course Name |
: |
Oxidative Stress and Antioxidant Defence |
|
| Course Code |
: |
BY-747 |
|
| Course Type |
: |
Optional |
|
| Level of Course |
: |
Second Cycle |
|
| Year of Study |
: |
1 |
|
| Course Semester |
: |
Fall (16 Weeks) |
|
| ECTS |
: |
6 |
|
| Name of Lecturer(s) |
: |
Prof.Dr. ELİF ORUÇ
|
|
| Learning Outcomes of the Course |
: |
Knows how the reactive oxygen species produce
understands oksidative stress and mode of action in the living organism
is able to make a relatinship between oxidative stress and metabolic disorder
|
|
| Mode of Delivery |
: |
Face-to-Face |
|
| Prerequisites and Co-Prerequisites |
: |
None |
|
| Recommended Optional Programme Components |
: |
None |
|
| Aim(s) of Course |
: |
The aim of this course to understand the mechanism of oxygen activation and reactive oxygen species, pathophysiology and reactive oxygen metabolites, and antioxidant defence system. |
|
| Course Contents |
: |
• what are oxygen radicals or reactive oxygen species?
• how reactive are oxygen radicals
• how are oxygen radicals generated in the cell
• how do oxidants medıate cellular damage
• how do cells protect themselves against oxygen radicals?
. involvement of oxidatıve stress in pathophysiological situations
|
|
| Language of Instruction |
: |
Turkish |
|
| Work Place |
: |
class |
|
|
Course Outline /Schedule (Weekly) Planned Learning Activities |
| Week | Subject | Student's Preliminary Work | Learning Activities and Teaching Methods |
|
1 |
What are oxygen radicals or reactive oxygen species |
Literature review |
Discussion |
|
2 |
the mechanism of oxygen activation and reactive oxygen species |
Literature review |
Discussion |
|
3 |
How do oxidants mediate cellular damage |
Literature review |
Discussion |
|
4 |
pathophysiology and reactive oxygen metabolites |
Literature review |
Discussion |
|
5 |
pro-oxidants: drugs, pesticides |
Literature review |
Discussion |
|
6 |
enzymatic antioxidant defence system |
Literature review |
Discussion |
|
7 |
non-enzymatic antioxidant defence system |
Literature review |
Discussion |
|
8 |
exam |
Literature review |
Discussion |
|
9 |
glutathione dependent catalysis |
Literature review |
Discussion |
|
10 |
Glutathione S-transferases in redox regulation |
Literature review |
Discussion |
|
11 |
Nitric oxide signaling and cellular redox state |
Literature review |
Discussion |
|
12 |
Calcium signaling, oxidative stress and apoptosis |
Literature review |
Discussion |
|
13 |
Metals and oxidative stress |
Literature review |
Discussion |
|
14 |
Selenoproteins |
Literature review |
Discussion |
|
15 |
Mitochondria and reactive oxygen species |
Literature review |
Discussion |
|
16/17 |
final exam |
|
|
|
|
| Contribution of the Course to Key Learning Outcomes |
| # | Key Learning Outcome | Contribution* |
|
1 |
Has the advanced hypothetical and applied knowledges in biology field |
4 |
|
2 |
Based on the bachelor´s level of qualification, develops and deepens the knowledge as a specialist in the biology |
4 |
|
3 |
Uses the theoretical and practical knowledge he expertises in biology |
4 |
|
4 |
Integrates and interprets the knowledge from different disciplines by his expertise in biology and generates new information. |
3 |
|
5 |
Solves the problems of biology by using research methods.
|
3 |
|
6 |
Carries out an independent study requires expertise on biology |
2 |
|
7 |
Develops and produces new strategic approaches and solves the unexpected problems in biology area by taking responsibilty |
3 |
|
8 |
Assesses the knowledge he expertises through critical approach and makes leadership solving problems related to biological environments. |
4 |
|
9 |
Systematically transfers the current developments in the field of biology and his/her studies to the person in biology field or other related fields by supporting qualitative and quantitative data |
4 |
|
10 |
Uses at least one foreign language to keep up to date with the field to take part in scientific and social interaction groups to share information at international levels |
2 |
|
11 |
Uses information and communication technologies as required in the biology field |
2 |
|
12 |
In biology, uses statistical software programme to carry out scientific research and also uses information and communication technology in proficiency level of knowledge and skills to critically evaluate |
1 |
|
13 |
Develops the strategy, policy and implementation plans in the issues related to the field of biology and treats the results obtained within standart of quality |
3 |
|
14 |
Uses the knowledge, problem solving, and / or practical skills obtained in the Biology Field in interdisciplinary studies. |
3 |
|
15 |
Oversees social, scientific, cultural and ethical values in order to collect, implement, interpret data in the Biology area |
4 |
|
16 |
Has the ability to formulate and solve the problems of biology in advanced level |
3 |
|
17 |
Has ability to use his advanced knowledge in biology field for thinking systematically and solve problems in multidisciplinary approaches |
2 |
| * Contribution levels are between 0 (not) and 5 (maximum). |
|
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