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| Course Description |
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| Course Name |
: |
Viral genetic |
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| Course Code |
: |
VİR-505 |
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| Course Type |
: |
Optional |
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| Level of Course |
: |
Second Cycle |
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| Year of Study |
: |
1 |
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| Course Semester |
: |
Fall and Spring (16 Weeks) |
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| ECTS |
: |
4 |
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| Name of Lecturer(s) |
: |
Prof.Dr. FÜGEN YARKIN
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| Learning Outcomes of the Course |
: |
Defines the genetic structure, physical and biological properties of viruses.
Lists the properties of DNA and RNA viruses.
Lists the types of mutations in viruses.
Defines antigenic drift and antigenic shift.
Explains the relationship between the genetic viruses.
Explains the relationship between viral gene products
Defines the viral genome mapping.
Defines the evolution of the viral genome.
Defines the non-genetic relationships between viruses.
Describes the genetic properties of clinically important viruses.
Defines the replication characteristics of viruses.
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| Mode of Delivery |
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Face-to-Face |
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| Prerequisites and Co-Prerequisites |
: |
None |
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| Recommended Optional Programme Components |
: |
None |
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| Aim(s) of Course |
: |
Learning important information and monitoring new developments about the genetic structure of viruses, mutation types, genetic and non-genetic relationships between viruses, the relationship between viral gene products, the evolution of the viral genome and genetic characteristics of the certain viruses, |
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| Course Contents |
: |
The genetic structure of viruses, characteristics of DNA and RNA viruses, types of mutation, antigenic drift and shift (reassortment), the genetic relationship between viruses, the relationship between viral gene products and complementation, mapping and evolution of the viral genome, non-genetic relations between the viruses, phenotypic mixing and replication of viruses are taught, and genetics of medically important Influenza, Hepatitis B, Human papillomavirus, rotavirus and Human immunodeficiency virus are described. |
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| Language of Instruction |
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Turkish |
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| Work Place |
: |
C.U Faculty of Medicine Department of Medical Microbiology convention hall and laboratories.
C.U Faculty of Medicine Department of Medical Virology laboratories. |
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Course Outline /Schedule (Weekly) Planned Learning Activities |
| Week | Subject | Student's Preliminary Work | Learning Activities and Teaching Methods |
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1 |
Genetic structure, physical and biological analysis of viruses |
Reading resources and lecture notes about the subject |
Verbal lecture, presentation |
|
2 |
Properties of DNA viruses |
Reading resources and lecture notes about the subject, |
Verbal lecture, presentation |
|
3 |
Properties of RNA viruses |
Reading resources and lecture notes about the subject, |
Verbal lecture, presentation |
|
4 |
Mutation types in viruses |
Reading resources and lecture notes about the subject, |
Verbal lecture, presentation |
|
5 |
Antigenic drift and antigenic shift (reassortment) |
Reading resources and lecture notes about the subject, |
Verbal lecture, presentation |
|
6 |
Genetic relationship between viruses: Recombination |
Reading resources and lecture notes about the subject, |
Verbal lecture, presentation |
|
7 |
The relationship between viral gene products and complementation |
Reading resources and lecture notes about the subject, |
Verbal lecture, presentation |
|
8 |
Midterm Exam |
Exam Preparaion |
Written Exam |
|
9 |
Viral genomic mapping
The evolution of the viral genome |
Reading resources and lecture notes about the subject,
Gathering information from the web |
Verbal lecture, presentation, discussion, |
|
10 |
Non-genetic relationships between viruses, phenotypic mixing |
Reading resources and lecture notes about the subject, |
Verbal lecture, presentation, discussion, |
|
11 |
Influenza virus genetics |
Reading resources and lecture notes about the subject,
Gathering information from the web |
Verbal lecture, presentation, discussion, |
|
12 |
Hepatitis B virus genetics |
Reading resources and lecture notes about the subject,
Gathering information from the web |
Verbal lecture, presentation, discussion, |
|
13 |
Genetics of Human Papillomavirus |
Reading resources and lecture notes about the subject,
Gathering information from the web |
Verbal lecture, presentation, discussion, |
|
14 |
Rotavirus genetics |
Reading resources and lecture notes about the subject,
Gathering information from the web |
Verbal lecture, presentation, discussion, |
|
15 |
Human immunodeficiency virus genetics
Replication in viruses |
Reading resources and lecture notes about the subject,
Gathering information from the web |
Verbal lecture, presentation, discussion, group work |
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16/17 |
Exam |
Exam Preparation |
Written Exam |
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Required Course Resources |
| Resource Type | Resource Name |
| Recommended Course Material(s) |
 Genel Viroloji, Şemsettin ustaçelebi, Pelikan yayınları, 2008
Moleküler klinik ve tanısal viroloji: Prof. Dr. Şemsettin USTAÇELEBİ, Güneş Tıp Kitabevi 2004
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| |
| Required Course Material(s) |
Cellular and Molecular Immunology, 6th Edition Authors: Abul K. Abbas, Andrew H. Lichtman, & Shiv Pillai, 2007
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Assessment Methods and Assessment Criteria |
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Semester/Year Assessments |
Number |
Contribution Percentage |
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Mid-term Exams (Written, Oral, etc.) |
1 |
60 |
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Homeworks/Projects/Others |
2 |
40 |
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Total |
100 |
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Rate of Semester/Year Assessments to Success |
40 |
| |
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Final Assessments
|
100 |
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Rate of Final Assessments to Success
|
60 |
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Total |
100 |
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| Contribution of the Course to Key Learning Outcomes |
| # | Key Learning Outcome | Contribution* |
|
1 |
Identifies morphological and physiological characteristics of microorganisms |
4 |
|
2 |
Identificates genomic structures of microorganisms |
5 |
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3 |
Explains microorganisms virulance factors and infection mechanisms. |
5 |
|
4 |
Defines the mechanisms of immune response and defense against microorganisms |
4 |
|
5 |
Lists the antimicrobial agents. |
0 |
|
6 |
Defines the mechanisms of resistance development against antimicrobial agents. |
4 |
|
7 |
Lists the microscopy, culture, serological and molecular diagnostic principles used in the laboratory diagnosis of infectious microorganisms. |
0 |
|
8 |
Lists microbiological tests for identification of microorganisms |
0 |
|
9 |
Implements and applies the methods used in the period from receipt of the clinical specimens up to identification of the causative agent . |
0 |
|
10 |
Prepares a suitable media, applicates the staining methods, biochemical tests and molecular diagnostic methods to identify microorganisms from clinical samples. |
0 |
|
11 |
Applies the biochemical tests and basic microbiological staining methods which are necessary for microbiological identification . |
0 |
|
12 |
Determines the microorganisms by using basic molecular diagnostic techniques. |
0 |
|
13 |
Works individually or as a team member related to the field. |
0 |
|
14 |
Carries out the missions given within the scope of research projects. |
0 |
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15 |
Develops a positive attitude and behaviour towards lifelong learning. |
0 |
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16 |
Evaluates own knowledge and new-learned knowledge in a critical view after graduating. |
0 |
|
17 |
Communicates effectively. |
0 |
|
18 |
Transfers their own ideas and developments in the field, and offers solutions visually and verbally supporting with qualitative and quantitative data. |
0 |
|
19 |
Applies ethical principles during study, evaluation and result sharing. |
0 |
| * Contribution levels are between 0 (not) and 5 (maximum). |
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| Student Workload - ECTS |
| Works | Number | Time (Hour) | Total Workload (Hour) |
| Course Related Works |
|
Class Time (Exam weeks are excluded) |
14 |
4 |
56 |
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Out of Class Study (Preliminary Work, Practice) |
14 |
2 |
28 |
| Assesment Related Works |
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Homeworks, Projects, Others |
2 |
4 |
8 |
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Mid-term Exams (Written, Oral, etc.) |
1 |
5 |
5 |
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Final Exam |
1 |
15 |
15 |
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Total Workload: | 112 |
| Total Workload / 25 (h): | 4.48 |
| ECTS Credit: | 4 |
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