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Course Description Course Name : ENZYMES AND ENZYME KINETICS Course Code : BİK-592 Course Type : Optional Level of Course : Second Cycle Year of Study : 1 Course Semester : Fall and Spring (16 Weeks) ECTS : 4 Name of Lecturer(s) : Prof.Dr. ABDULLAH TULİ Prof.Dr. LEVENT KAYRIN Learning Outcomes of the Course : describes enzymes describes the structure and functions of enzymes gains knowledge about factors that effect enymatic reactions performs kinetic examination of enzymes that have one or multiple substrates interpretes allosteric enzymes describes enzyme inhibition discusses the importance of enzymes in normal pathologic conditions Mode of Delivery : Face-to-Face Prerequisites and Co-Prerequisites : None Recommended Optional Programme Components : None Aim(s) of Course : the aim of this course is to enable students comprehend the features of enzymes and enzyme kinetics Course Contents : introduction to enzymology, enzymes and their classification, principles of enzyme catalysation, enzyme kinetics, factors that effect enzymatic rate, enzyme inhibitions, enzymatic catalyse of multisubstrate reactions, methods for measurement of enzyme activity, control enzymes and mechanisms, purification of enzymes, isozymes, clinical usage of enzymes. Language of Instruction : Turkish Work Place : Medical Faculty, Seminar Hall of Biochemistry Department   Course Outline /Schedule (Weekly) Planned Learning Activities Week Subject Student's Preliminary Work Learning Activities and Teaching Methods 1 introduction to enzymology, term of enzyme and classification of enzymes listening and interpretetion, preparing slides, processing, critical thinking , preparing questions lesson,discussion lesson, laboratory, assignment 2 principles of enzymatic catalysis listening and interpretetion, preparing slides, processing, critical thinking , preparing questions lesson, discussion lesson, laboratory, assignment 3 enzyme kinetics and factors that effect enzymatic rate listening and interpretetion, preparing slides, processing, critical thinking, preparing questions lesson, discussion lesson, laboratory, asignment 4 enzyme inhibitions listening and interpretetion, preparing slides, processing, critical thinking , preparing questions lesson, discussion lesson, laboratory, assignment 5 enzyme inhibitions listening and interpretetion, preparing slides, processing, critical thinking , preparing questions lesson, discussion lesson, laboratory, assignment 6 enzyme catalyse reactions with multi-substrate listening and interpretetion, preparing slides, processing, critical thinking , preparing questions lesson, discussion lesson, laboratory, assignment 7 enzyme catalyse reactions with multi-substrate listening and interpretetion, preparing slides, processing, critical thinking , preparing questions lesson, discussion lesson, laboratory, assignment 8 mid-term examination preparing text questions classic exam 9 measurement methods for enzyme activity listening and interpretetion, preparing slides, processing, critical thinking , preparing questions lesson, discussion lesson, laboratory, assignment 10 control enzymes and mechanisms listening and interpretetion, preparing slides, processing, critical thinking, preparing questions lesson, discussion lesson, laboratory, assignment 11 control enzymes and mechanisms listening and interpretetion, preparing slides, processing, critical thinking , preparing questions lesson, discussion lesson, laboratory, assignment 12 purification of enzymes listening and interpretetion, preparing slides, processing, critical thinking , preparing questions lesson, discussion lesson, laboratory, assignment 13 isozymes listening and interpretetion, preparing slides, processing, critical thinking , preparing questions lesson, discussion lesson, laboratory, assignment 14 medical usage of enzymes listening and interpretetion, preparing slides, processing, critical thinking, preparing questions lesson, discussion lesson, laboratory, assignment 15 medical usage of enzymes listening and interpretetion, preparing slides, processing, critical thinking , preparing questions lesson, discussion lesson, laboratory, assignment 16/17 final examination preparing text questions classic exam   Required Course Resources Resource Type Resource Name Recommended Course Material(s)  Burtis CA, Achwood ER. Tietz Textbook of Clinical Chemistry, 3rd Ed., Saunders, Philadelphia, 1996.  Segel IH. Biochemical Calculations, John Wiley & Sons, 1976.  Nelson DL, Cox MM. Lehninger Principles of Biochemistry, 6th Ed., W. H. Freeman and Company, 2013.  Palmer T. Understanding Enzymes, 4th Ed., Prentice Hall,1995.  Databases of Internet and Library Required Course Material(s)   Assessment Methods and Assessment Criteria Semester/Year Assessments Number Contribution Percentage     Mid-term Exams (Written, Oral, etc.) 1 50     Homeworks/Projects/Others 4 50 Total 100 Rate of Semester/Year Assessments to Success 40   Final Assessments 100 Rate of Final Assessments to Success 60 Total 100   Contribution of the Course to Key Learning Outcomes # Key Learning Outcome Contribution* 1 Applies innovations in laboratory processes by doing research. 5 2 Comprehends the interaction of biochemistry with the other scientific fields. 3 3 Knows experimental methods in biochemistry. 3 4 Takes part in in-vitro/in-vivo animal research studies. 0 5 Carries out studies in the field of biochemistry as a member of a team. 3 6 Gains ongoing professional skills. 5 7 Comprehends basic information about the field of biochemistry. 5 8 Interprets the factors and phases that effect the laboratory results. 0 9 Uses laboratory tools. 0 10 Knows the ethical and legal characteristics of laboratory processes, and interpretes economical value of these processes for the country. 0 11 Supports a scientific research. 3 12 Interpretes scientific research results which are carried out. 3 13 Generates a report from the conclusion of the scientific research. 3 14 Knows biochemical sampling rules. 0 15 Studies and makes research in laboratory settings. 3 16 Corporates with the other members of the team in an efficient, sensitive and respectfull way. 3 17 Interpretes and corrolates biochemical data and theoretical concept. 0 * Contribution levels are between 0 (not) and 5 (maximum).   Student Workload - ECTS Works Number Time (Hour) Total Workload (Hour) Course Related Works     Class Time (Exam weeks are excluded) 14 2 28     Out of Class Study (Preliminary Work, Practice) 14 1 14 Assesment Related Works     Homeworks, Projects, Others 4 5 20     Mid-term Exams (Written, Oral, etc.) 1 10 10     Final Exam 1 20 20 Total Workload: 92 Total Workload / 25 (h): 3.68 ECTS Credit: 4