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Course Description Course Name : Biology and Genetics of Aging Course Code : BİO524 Course Type : Optional Level of Course : Second Cycle Year of Study : 1 Course Semester : Fall and Spring (16 Weeks) ECTS : 5 Name of Lecturer(s) : Prof.Dr. HÜSNÜ ÜMİT LÜLEYAP Learning Outcomes of the Course : Knows aging patterns. Knows the factors affecting aging. Knows the opinions and theories related with Genetics and Endocrine DNA repair and free radical. Knows the multiple effects of calorie restriction. Mode of Delivery : Face-to-Face Prerequisites and Co-Prerequisites : BİO501 Principles of Medical Biology BİO502 Principles of Medical Genetics Recommended Optional Programme Components : None Aim(s) of Course : To examine the aging biology and genetics at the level of cell and organism Course Contents : Aging patterns, multiple factors effecting aging, opinions and theories related with genetics and endocrine DNA repair and free radicals, multiple effects of calorie restriction Language of Instruction : Turkish Work Place : Seminar room   Course Outline /Schedule (Weekly) Planned Learning Activities Week Subject Student's Preliminary Work Learning Activities and Teaching Methods 1 The evolutionary story of aging and death Preparing presentation, Preparing of lecture notes, Brain storming Standard classroom technologies, multimedia tools, projector, computer-based lecture and discussion 2 The factors effecting aging Preparing presentation, Preparing lecture notes, Brain storming Standard classroom technologies, multimedia tools, projector, computer-based lecture and discussion 3 The genetics theory, telomere and aging Preparing presentation, Preparing lecture notes, Brain storming Standard classroom technologies, multimedia tools, projector, computer-based lecture and discussion 4 The effects of DNA damage and repair systems Preparing presentation, Preparing lecture notes, Brain storming Standard classroom technologies, multimedia tools, projector, computer-based lecture and discussion 5 Free radicals and their neutralization, the effect of neural system on the length of life Preparing presentation, Preparing lecture notes, Brain storming Standard classroom technologies, multimedia tools, projector, computer-based lecture and discussion 6 RNA destruction and aging Preparing presentation, Preparing lecture notes, Brain storming Standard classroom technologies, multimedia tools, projector, computer-based lecture and discussion 7 The effects of calorie restrictions Preparing presentation, Preparing lecture notes, Brain storming Standard classroom technologies, multimedia tools, projector, computer-based lecture and discussion 8 Aging and DNA metilation Preparing presentation, Preparing lecture notes, Brain storming Standard classroom technologies, multimedia tools, projector, computer-based lecture and discussion 9 Aging and DNA metilation Preparing presentation, Preparing lecture notes, Brain storming Standard classroom technologies, multimedia tools, projector, computer-based lecture and discussion 10 Mid-term exam Preparing multiple-choice questions Written exam 11 Aging and apoptosis Preparing presentation, Preparing lecture notes, Brain storming Standard classroom technologies, multimedia tools, projector, computer-based lecture and discussion 12 Aging and apoptosis Preparing presentation, Preparing lecture notes, Brain storming Standard classroom technologies, multimedia tools, projector, computer-based lecture and discussion 13 Gene interactions related with aging Preparing presentation, Preparing lecture notes, Brain storming Standard classroom technologies, multimedia tools, projector, computer-based lecture and discussion 14 Lamina structure and aging diseases Preparing presentation, Preparing lecture notes, Brain storming Standard classroom technologies, multimedia tools, projector, computer-based lecture and discussion 15 Results and Discussion Brain storming, Revision Standard classroom technologies, multimedia tools, projector, computer-based lecture and discussion 16/17 Final exam Preparing multiple-choice questions Written exam   Required Course Resources Resource Type Resource Name Recommended Course Material(s)  Lüleyap, Ü. Principles of Molecular Genetics. Nobel Yayınevi, 2008.  Guarente LP, Partridge L and Wallace DC. Molecular Biology of Aging. Cold Spring Harbor Laboratory Press, 2008. Required Course Material(s)   Assessment Methods and Assessment Criteria Semester/Year Assessments Number Contribution Percentage     Mid-term Exams (Written, Oral, etc.) 1 60     Homeworks/Projects/Others 5 40 Total 100 Rate of Semester/Year Assessments to Success 40   Final Assessments 100 Rate of Final Assessments to Success 60 Total 100   Contribution of the Course to Key Learning Outcomes # Key Learning Outcome Contribution* 1 Explains theorical debates of three main areas (philosophy, sociology, psychology) in relation to today´s problems 2 2 Knows the functions of tissues and organ systems. 3 3 Knows the structure of the genetic material. 5 4 Knows the genetic diseases and the genes that cause genetic diseases and disorders. 5 5 Is able to conduct molecular and cytogenetic diagnosis analysis. 2 6 Knows what numerical and structural abnormalities of the autosomes and the sex chromosomes mean and explain them. 0 7 Is able to do DNA isolation from all types of tissue. 0 8 Is able to perform PCR. 0 9 Is able to perform and interpret agarose and polyacrylamide gel electrophoresis. 0 10 Is able to measure the DNA obtained from tissues using a spectrophotometer. 0 11 Is capable of interpreting and implementing QF-PCR technique. 0 12 Is able to cell culture from blood, amniotic, chorionic villus biopsy specimens, and obtain chromosome preparation. 0 13 Is able to recognize and interpret all human chromosomes from the preparations derived from chromosome karyotype analysis. 0 14 Learns how to write and comment on a scientific article. 3 15 Knows the structure of genes. 5 16 Knows the chromosome and gene mutations. 5 17 Knows patterns of inheritance (autosomal dominant, autosomal recessive, sex-linked dominant and recessive inheritance models). 5 * Contribution levels are between 0 (not) and 5 (maximum).   Student Workload - ECTS Works Number Time (Hour) Total Workload (Hour) Course Related Works     Class Time (Exam weeks are excluded) 14 3 42     Out of Class Study (Preliminary Work, Practice) 14 4 56 Assesment Related Works     Homeworks, Projects, Others 5 5 25     Mid-term Exams (Written, Oral, etc.) 1 1 1     Final Exam 1 1 1 Total Workload: 125 Total Workload / 25 (h): 5 ECTS Credit: 5