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| Course Description |
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| Course Name |
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Developmental Biology an Genetics |
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| Course Code |
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BİO523 |
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| Course Type |
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Optional |
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| Level of Course |
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Second Cycle |
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| Year of Study |
: |
1 |
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| Course Semester |
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Fall and Spring (16 Weeks) |
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| ECTS |
: |
4 |
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| Name of Lecturer(s) |
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Prof.Dr. DAVUT ALPTEKİN
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| Learning Outcomes of the Course |
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Has general knowledge of developmental biology and genetics.
Knows the factors that affect development.
Knows the features that are important for the development of stem cells.
Is aware of the animal models Drosophila melanogaster and Caenorhabditis elegans, which are important for developmental biology and genetics.
Knows Apoptosis (programmed cell death).
Knows genes and genomes.
Knows what epigenetic inheritance is.
Knows how genes are silenced, and what methylation, acetylation, ubiquitinasyon are.
Knows, what RNA and virus-mediated gene silencing are.
Knows what genomic imprinting is.
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| Mode of Delivery |
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Face-to-Face |
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| Prerequisites and Co-Prerequisites |
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None |
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| Recommended Optional Programme Components |
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None |
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| Aim(s) of Course |
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To give students an overview of Developmental Biology and Genetics, variations occurring in the animal´s development process and to provide information about the genes which affect those variations. To inform them about stem cells, and give examples of development of animal models . To explain the changes that occur during development in different animal species. To explain the importance of apoptosis and the effective genes in apoptosis. To explain the silencing of genes and gene silencing mechanisms during development. |
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| Course Contents |
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An overview of developmental biology and genetics organizations. Amended stem cells during development and their differentiation . Factors affecting development. The biology and genetics of Drosophyla melanogaster; one of the animal models which explains development. The biology and genetics of Caenorhabditis elegans; one of the animal models which explains development . Genes that affect development. Apoptosis and apoptosis genes. Gene, genome, inheritance, epigenetic inheritance. Silencing of genes. Genomic imprinting. RNA-mediated gene silencing. Gene silencing viruses. |
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| Language of Instruction |
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Turkish |
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| Work Place |
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Seminar room |
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Course Outline /Schedule (Weekly) Planned Learning Activities |
| Week | Subject | Student's Preliminary Work | Learning Activities and Teaching Methods |
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1 |
An overview of developmental biology and genetics organizations. |
Slide preparation |
Standard classroom technologies, multimedia tools, computer-based lecture and discussion. |
|
2 |
Amended stem cells and their differentiation during development. |
Slide preparation |
Standard classroom technologies, multimedia tools, computer-based lecture and discussion. |
|
3 |
Factors affecting development. |
Slide preparation |
Standard classroom technologies, multimedia tools, computer-based lecture and discussion. |
|
4 |
The biology and genetics of Drosophyla melanogaster; one of the animal models which explains development. |
Slide preparation |
Standard classroom technologies, multimedia tools, computer-based lecture and discussion. |
|
5 |
The biology and genetics of Caenorhabditis elegans; one of the animal models which explains development . |
Slide preparation |
Standard classroom technologies, multimedia tools, computer-based lecture and discussion. |
|
6 |
Genes that affect development. |
Slide preparation |
Standard classroom technologies, multimedia tools, computer-based lecture and discussion. |
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7 |
Genes that affect development. |
Slide preparation |
Standard classroom technologies, multimedia tools, computer-based lecture and discussion. |
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8 |
Midterm exam |
Preparation of multiple-choice questions |
Written exam with multiple choice questions, oral exam. |
|
9 |
Apoptosis and apoptosis genes. |
Slide preparation |
Standard classroom technologies, multimedia tools, computer-based lecture and discussion. |
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10 |
Gene and genome. |
Slide preparation |
Standard classroom technologies, multimedia tools, computer-based lecture and discussion. |
|
11 |
What is the inheritance, epigenetic inheritance. |
Slide preparation |
Standard classroom technologies, multimedia tools, computer-based lecture and discussion. |
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12 |
Silencing of genes. |
Slide preparation |
Standard classroom technologies, multimedia tools, computer-based lecture and discussion. |
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13 |
Genomic imprinting.
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Slide preparation |
Standard classroom technologies, multimedia tools, computer-based lecture and discussion. |
|
14 |
RNA-mediated gene silencing. |
Slide preparation |
Standard classroom technologies, multimedia tools, computer-based lecture and discussion. |
|
15 |
Gene silencing with viruses |
Slide preparation |
Standard classroom technologies, multimedia tools, computer-based lecture and discussion. |
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16/17 |
Final exam |
Preparation of multiple-choice questions |
Written exam with multiple choice questions, oral exam. |
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Required Course Resources |
| Resource Type | Resource Name |
| Recommended Course Material(s) |
 Campbell N.A. and Reece J.B. Biology (Sixth Edition), Ed. Etunç Gündüz, Ali Demirsoy, İsmail Türkan. Palme Yayıncılık, Ankara , 2006.
Gilbert SF. Developmental Biology. Third Edition. Sinauer associates, Inc.Sunderland, Massachusetts. p 891, 1991.
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| Required Course Material(s) | |
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Assessment Methods and Assessment Criteria |
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Semester/Year Assessments |
Number |
Contribution Percentage |
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Mid-term Exams (Written, Oral, etc.) |
1 |
100 |
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Homeworks/Projects/Others |
2 |
0 |
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Total |
100 |
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Rate of Semester/Year Assessments to Success |
40 |
| |
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Final Assessments
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100 |
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Rate of Final Assessments to Success
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60 |
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Total |
100 |
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| Contribution of the Course to Key Learning Outcomes |
| # | Key Learning Outcome | Contribution* |
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1 |
Explains theorical debates of three main areas (philosophy, sociology, psychology) in relation to today´s problems
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5 |
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2 |
Knows the functions of tissues and organ systems. |
1 |
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3 |
Knows the structure of the genetic material. |
5 |
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4 |
Knows the genetic diseases and the genes that cause genetic diseases and disorders. |
4 |
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5 |
Is able to conduct molecular and cytogenetic diagnosis analysis. |
2 |
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6 |
Knows what numerical and structural abnormalities of the autosomes and the sex chromosomes mean and explain them. |
2 |
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7 |
Is able to do DNA isolation from all types of tissue. |
2 |
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8 |
Is able to perform PCR. |
0 |
|
9 |
Is able to perform and interpret agarose and polyacrylamide gel electrophoresis. |
0 |
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10 |
Is able to measure the DNA obtained from tissues using a spectrophotometer. |
0 |
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11 |
Is capable of interpreting and implementing QF-PCR technique. |
0 |
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12 |
Is able to cell culture from blood, amniotic, chorionic villus biopsy specimens, and obtain chromosome preparation. |
0 |
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13 |
Is able to recognize and interpret all human chromosomes from the preparations derived from chromosome karyotype analysis. |
0 |
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14 |
Learns how to write and comment on a scientific article. |
2 |
|
15 |
Knows the structure of genes. |
5 |
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16 |
Knows the chromosome and gene mutations. |
2 |
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17 |
Knows patterns of inheritance (autosomal dominant, autosomal recessive, sex-linked dominant and recessive inheritance models). |
2 |
| * Contribution levels are between 0 (not) and 5 (maximum). |
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| Student Workload - ECTS |
| Works | Number | Time (Hour) | Total Workload (Hour) |
| Course Related Works |
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Class Time (Exam weeks are excluded) |
14 |
2 |
28 |
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Out of Class Study (Preliminary Work, Practice) |
14 |
4 |
56 |
| Assesment Related Works |
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Homeworks, Projects, Others |
2 |
4 |
8 |
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Mid-term Exams (Written, Oral, etc.) |
1 |
1 |
1 |
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Final Exam |
1 |
1 |
1 |
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Total Workload: | 94 |
| Total Workload / 25 (h): | 3.76 |
| ECTS Credit: | 4 |
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