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| Course Description |
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| Course Name |
: |
Nutritional Genetics |
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| Course Code |
: |
BİO529 |
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| Course Type |
: |
Optional |
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| Level of Course |
: |
Second Cycle |
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| Year of Study |
: |
1 |
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| Course Semester |
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Fall and Spring (16 Weeks) |
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| ECTS |
: |
5 |
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| Name of Lecturer(s) |
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Assoc.Prof.Dr. AYFER PAZARBAŞI
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| Learning Outcomes of the Course |
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Describes gene diet interactions
Understands the association between SNPs and human diseases
Understands diet-methilation and cancer interactions.
Understands diet and epigenetic relationship
Learns genetics of obesity
Learns genetics of osteoporosis
Learns genetics of hypertension
Knows dietary approaches to modify cardiovascular biological markers.
Knows folate metabolism and associated diseases
Learns iron homeostasis and hemochromatosis.
Knows and explains gene samples with Lipid metabolism and polymorphisms.
Learns the genetics of diabetes and lactose intolerance.
Understands the association between SNPs and human diseases.
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| Mode of Delivery |
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Face-to-Face |
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| Prerequisites and Co-Prerequisites |
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BİO501 Principles of Medical Biology
BİO502 Principles of Medical Genetics
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| Recommended Optional Programme Components |
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None |
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| Aim(s) of Course |
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Gene-diet interactions in nutrigenetics, Association of SNPs with human diseases, Diet- methilation-cancer interactions, Genetics of osteoporosis, diabetes and obesity, Genetic variations related to hypertension, Healthy diet for cardiovascular health, Lactose intolerance, Folate metabolism and neural tube defects, Iron homeostasis, hemochromatosis, Lipid metabolism, Examples of polymorphic genes. |
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| Course Contents |
: |
Gene-diet interactions in nutrigenetics, Association of SNPs with human diseases, Diet- methilation-cancer interactions, Genetics of osteoporosis, diabetes and obesity, Genetic variations related to hypertension, Healthy diet for cardiovascular health, Lactose intolerance, Folate metabolism and neural tube defects, Iron homeostasis, hemochromatosis, Lipid metabolism, Examples of polymorphic genes. |
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| Language of Instruction |
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Turkish |
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| Work Place |
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Seminar room |
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Course Outline /Schedule (Weekly) Planned Learning Activities |
| Week | Subject | Student's Preliminary Work | Learning Activities and Teaching Methods |
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1 |
To describe the gene-diet relationship |
Literature review and reading |
Pages to be read, web content to be examined, presentations, sample |
|
2 |
Understanding the association between SNPs and human diseases |
Literature review and reading |
Pages to be read, web content to be examined, presentations, sample |
|
3 |
Understanding the association between diet-methylation and cancer |
Literature review and reading |
Pages to be read, web content to be examined, presentations, sample |
|
4 |
Understanding the association between diet and epigenetics |
Literature review and reading |
Pages to be read, web content to be examined, presentations, sample |
|
5 |
To learn the genetics of obesity |
Literature review and reading |
Pages to be read, web content to be examined, presentations, sample |
|
6 |
To learn the genetics of osteoporosis |
Literature review and reading |
Pages to be read, web content to be examined, presentations, sample |
|
7 |
To learn the genetics of hypertension and lipid metabolism |
Literature review and reading |
Pages to be read, web content to be examined, presentations, sample |
|
8 |
Quiz |
Preparing multiple-choice questions |
Written exam |
|
9 |
To learn about dietary approaches to modify cardiovascular biological markers. |
Literature review and reading |
Pages to be read, web content to be examined, presentations, sample |
|
10 |
To learn about folate metabolism and related diseases |
Literature review and reading |
Pages to be read, web content to be examined, presentations, sample |
|
11 |
To learn about iron homeostasis and hemochromatosis |
Literature review and reading |
Pages to be read, web content to be examined, presentations, sample |
|
12 |
To learn about lactose intolerance |
Literature review and reading |
Pages to be read, web content to be examined, presentations, sample |
|
13 |
To know and explain gene samples with polymorphisms |
Literature review and reading |
Pages to be read, web content to be examined, presentations, sample |
|
14 |
Learning Diabetes Genetics |
Literature review and reading |
Pages to be read, web content to be examined, presentations, sample |
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15 |
Revision |
Brainstorming |
Discussion and questions |
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16/17 |
Final exam |
Preparing multiple-choice questions |
Written exam |
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Required Course Resources |
| Resource Type | Resource Name |
| Recommended Course Material(s) |
 Lüleyap, Ü. Principles of Molecular Genetics. Nobel Yayınevi, 2008
Kasap H, Kasap M, Demirhan O, Alptekin D, Lüleyap Ü, Pazarbaşı A, Güzel Aİ. Medical Biology and Genetics. Editör Halil Kasap, Nobel Tıp Kitabevi, Adana, 2010.
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| Required Course Material(s) |
Martin Kussmann and Peter J.Van Bladeren. The extended nutrigenomics–understanding the inter play between the genomes of food, gutmicrobes, and human host. Frontiers in Genetics. 2011(2): 1-21.
Coşkun T. Nutritional Genomics. Çocuk Sağlığı ve Hastalıkları Dergisi, 50: 01-56, 2007.
L. Joseph Su, Somdat Mahabir, Gary L.Ellison, Laura A. Mc Guinn and Britt C Reid. Epigenetic contributions to the relationship between cancer and dietary intake of nutrients, bioactive food components, and environmental toxicants. Frontiers in Genetics. 2012(2): 1-12.
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Assessment Methods and Assessment Criteria |
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Semester/Year Assessments |
Number |
Contribution Percentage |
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Mid-term Exams (Written, Oral, etc.) |
1 |
80 |
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Homeworks/Projects/Others |
5 |
20 |
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Total |
100 |
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Rate of Semester/Year Assessments to Success |
40 |
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Final Assessments
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100 |
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Rate of Final Assessments to Success
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60 |
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Total |
100 |
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| Contribution of the Course to Key Learning Outcomes |
| # | Key Learning Outcome | Contribution* |
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1 |
Explains theorical debates of three main areas (philosophy, sociology, psychology) in relation to today´s problems
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2 |
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2 |
Knows the functions of tissues and organ systems. |
2 |
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3 |
Knows the structure of the genetic material. |
5 |
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4 |
Knows the genetic diseases and the genes that cause genetic diseases and disorders. |
5 |
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5 |
Is able to conduct molecular and cytogenetic diagnosis analysis. |
3 |
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6 |
Knows what numerical and structural abnormalities of the autosomes and the sex chromosomes mean and explain them. |
3 |
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7 |
Is able to do DNA isolation from all types of tissue. |
1 |
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8 |
Is able to perform PCR. |
1 |
|
9 |
Is able to perform and interpret agarose and polyacrylamide gel electrophoresis. |
1 |
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10 |
Is able to measure the DNA obtained from tissues using a spectrophotometer. |
1 |
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11 |
Is capable of interpreting and implementing QF-PCR technique. |
1 |
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12 |
Is able to cell culture from blood, amniotic, chorionic villus biopsy specimens, and obtain chromosome preparation. |
1 |
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13 |
Is able to recognize and interpret all human chromosomes from the preparations derived from chromosome karyotype analysis. |
1 |
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14 |
Learns how to write and comment on a scientific article. |
1 |
|
15 |
Knows the structure of genes. |
5 |
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16 |
Knows the chromosome and gene mutations. |
3 |
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17 |
Knows patterns of inheritance (autosomal dominant, autosomal recessive, sex-linked dominant and recessive inheritance models). |
3 |
| * Contribution levels are between 0 (not) and 5 (maximum). |
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| Student Workload - ECTS |
| Works | Number | Time (Hour) | Total Workload (Hour) |
| Course Related Works |
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Class Time (Exam weeks are excluded) |
14 |
3 |
42 |
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Out of Class Study (Preliminary Work, Practice) |
14 |
4 |
56 |
| Assesment Related Works |
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Homeworks, Projects, Others |
5 |
4 |
20 |
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Mid-term Exams (Written, Oral, etc.) |
1 |
1 |
1 |
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Final Exam |
1 |
1 |
1 |
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Total Workload: | 120 |
| Total Workload / 25 (h): | 4.8 |
| ECTS Credit: | 5 |
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