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Course Description Course Name : Molecular Endocrinology Course Code : BT-545 Course Type : Optional Level of Course : Second Cycle Year of Study : 1 Course Semester : Fall (16 Weeks) ECTS : 6 Name of Lecturer(s) : Prof.Dr. ALİ KEMAL TOPALOĞLU Learning Outcomes of the Course : Knows basic lab techniques in Molecular Endocrinology Knows basic inheritance patterns Knows genotype-phenotype relationship Knows autozygosity mapping Are conscious regarding bioethics. Mode of Delivery : Face-to-Face Prerequisites and Co-Prerequisites : None Recommended Optional Programme Components : None Aim(s) of Course : To provide students basic concepts and laboratory applications in Molecular Endocrinology. Course Contents : Evaluation and determination of Endocrine disease phenotypes. Drawing pedigrees and deermining inheritance pattern. PCR and Sanger Sequencing. Exome sequencing. Evaluation of exome data. Identification of mutant gene responsible for the phenotype. Language of Instruction : Turkish Work Place : Classroom and laboratory   Course Outline /Schedule (Weekly) Planned Learning Activities Week Subject Student's Preliminary Work Learning Activities and Teaching Methods 1 Evaluation and determination of Endocrine disease phenotypes.1 Reading Class 2 Evaluation and determination of Endocrine disease phenotypes.2 Reading Class 3 Evaluation and determination of Endocrine disease phenotypes.3 Reading Class 4 Evaluation and determination of Endocrine disease phenotypes.4 Reading Class 5 Drawing pedigrees and deermining inheritance pattern. 1 Reading Class 6 Drawing pedigrees and deermining inheritance pattern. 2 Reading Class 7 PCR and Sanger Sequencing. 1 Reading Lab 8 PCR and Sanger Sequencing. 2 Reading Lab 9 PCR and Sanger Sequencing. 3 Reading Lab 10 Exome sequencing. Evaluation of exome data. 1 Reading Class 11 Exome sequencing. Evaluation of exome data. 2 Reading Class 12 Exome sequencing. Evaluation of exome data. 3 Reading Class 13 Identification of mutant gene responsible for the phenotype. 1 Reading Class 14 Identification of mutant gene responsible for the phenotype. 2 Reading Class 15 Identification of mutant gene responsible for the phenotype. 3 Reading Class 16/17 Identification of mutant gene responsible for the phenotype. 4 Reading Class   Required Course Resources Resource Type Resource Name Recommended Course Material(s)  1. Strachan T., Read, A.P, 2010, Human Molecular Genetics Garland Sciences  2. Sperling M. 2008, Pediatric Endocrinology, Saunders Required Course Material(s)   Assessment Methods and Assessment Criteria Semester/Year Assessments Number Contribution Percentage     Mid-term Exams (Written, Oral, etc.) 1 60     Homeworks/Projects/Others 3 40 Total 100 Rate of Semester/Year Assessments to Success 40   Final Assessments 100 Rate of Final Assessments to Success 60 Total 100   Contribution of the Course to Key Learning Outcomes # Key Learning Outcome Contribution* 1 Evaluates and directs his level of learning in the field of knowledge and skills with his expert level critically. 4 2 Transfers current developments in the field of his work, supporting them with quantitative and qualitative data, systematically to the area outside of the field, written, orally and visually. 4 3 Follows national and international publications and attends social interactions and scientific studies in international level, communicates in at least in one foreign language in order to share studies on international base. 4 4 Uses advanced information and communication technologies along with the required level of their computer software. 4 5 Uses the knowledge in his field for problem solving and / or practical skills in interdisciplinary studies. 4 6 Improves common knowledge accumulation concerning the Biotechnology in the frame of basic theory and practices. 4 7 Is aware of scientific, ethical and social values and handles research process with this frame. 3 8 Handles theories, hypothesis, opinions in the field of Biotechnology with an objective sceptic, logical, analytical manner and evaluates them in critical point of view. 4 9 Gains comprehensive information about natural and applied sciences and its limits with modern techniques and methods applied. 5 10 Improves and increases the knowledge to an expert level in the field of biotechnology 4 11 Understands the interdisciplinary interaction associated with biotechnology. 4 12 Integrates and interprets the knowledge from different disciplines by his expertrise in biology and generate new information 4 13 Analizes the problems encountered in the field of research methods. 5 14 Carries out a study requiring expertise in the field independently. 4 15 Developes new strategic approaches and takes resposibility for analitical solutions for unpredictable complicated problems encountered in applications related to biotechnology. 4 16 Demonstrates leadership in the required environment to solve problems associated with biotechnology. 4 * Contribution levels are between 0 (not) and 5 (maximum).   Student Workload - ECTS Works Number Time (Hour) Total Workload (Hour) Course Related Works     Class Time (Exam weeks are excluded) 14 4 56     Out of Class Study (Preliminary Work, Practice) 14 2 28 Assesment Related Works     Homeworks, Projects, Others 3 10 30     Mid-term Exams (Written, Oral, etc.) 1 14 14     Final Exam 1 14 14 Total Workload: 142 Total Workload / 25 (h): 5.68 ECTS Credit: 6