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| Course Description |
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| Course Name |
: |
Radiobiology |
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| Course Code |
: |
MEDF-508 |
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| Course Type |
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Optional |
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| Level of Course |
: |
Sub-Level (Undergraduate Degree) |
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| Year of Study |
: |
1 |
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| Course Semester |
: |
Spring (16 Weeks) |
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| ECTS |
: |
4 |
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| Name of Lecturer(s) |
: |
Prof.Dr. İSMAİL GÜNAY
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| Learning Outcomes of the Course |
: |
Learns physics and chemistry of radiation absorption
Learns molecular mechanisms of DNA and chromosome damage and repair
Understands cell survival curves
Understands fractionated radiation and the dose-rate effect
Comprehends oxygen effect and reoxygenation
Comprehends heritable effects of radiation
Comprehends the effects of radiation on the embryo and fetus
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| Mode of Delivery |
: |
Face-to-Face |
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| Prerequisites and Co-Prerequisites |
: |
None |
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| Recommended Optional Programme Components |
: |
None |
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| Aim(s) of Course |
: |
The aim of the course is to teach the effects of radiation molecular and cell, cell survival curves, to understand and apply fractionated radiation and dose-rate effect. |
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| Course Contents |
: |
Physics and chemistry of radiation absorption, Molecular mechanisms of DNA and chromosome damage and repair, Cell survival curves, Radiosensitivity and cell age in the mitotic cycle, Fractionated radiation and the dose-rate effect, Oxygen effect and reoxygenation, Radiation carcinogenesis, Heritable effects of radiation, Effects of radiation on the embryo and fetus, quiz, final exam, assignment. |
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| Language of Instruction |
: |
Turkish |
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| Work Place |
: |
Classroom |
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Course Outline /Schedule (Weekly) Planned Learning Activities |
| Week | Subject | Student's Preliminary Work | Learning Activities and Teaching Methods |
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1 |
Physics and chemistry of radiation absorption |
Student reads related chapter previously |
lecturing, interactive teaching, solving examples, discussion |
|
2 |
Molecular mechanisms of DNA and chromosome damage and repair |
Student reads related chapter previously |
lecturing, interactive teaching, solving examples, discussion |
|
3 |
Molecular mechanisms of DNA and chromosome damage and repair |
Student reads related chapter previously |
lecturing, interactive teaching, solving examples, discussion |
|
4 |
Cell survival curves |
Student reads related chapter previously |
lecturing, interactive teaching, solving examples, discussion |
|
5 |
Cell survival curves |
Student reads related chapter previously |
lecturing, interactive teaching, solving examples, discussion |
|
6 |
Radiosensitivity and cell age in the mitotic cycle |
Student reads related chapter previously |
lecturing, interactive teaching, solving examples, discussion |
|
7 |
Fractionated radiation and the dose-rate effect |
Student reads related chapter previously |
lecturing, interactive teaching, solving examples, discussion |
|
8 |
Fractionated radiation and the dose-rate effect |
Student reads related chapter previously |
lecturing, interactive teaching, solving examples, discussion |
|
9 |
Fractionated radiation and the dose-rate effect |
Student reads related chapter previously |
lecturing, interactive teaching, solving examples, discussion |
|
10 |
Quiz |
Student reads related chapter previously |
written exam |
|
11 |
Oxygen effect and reoxygenation |
Student reads related chapter previously |
lecturing, interactive teaching, solving examples, discussion |
|
12 |
Oxygen effect and reoxygenation |
Student reads related chapter previously |
lecturing, interactive teaching, solving examples, discussion |
|
13 |
Radiation carcinogenesis |
Student reads related chapter previously |
lecturing, interactive teaching, solving examples, discussion |
|
14 |
Heritable effects of radiation |
Student reads related chapter previously |
lecturing, interactive teaching, solving examples, discussion |
|
15 |
Effects of radiation on the embryo and fetus |
Student reads related chapter previously |
lecturing, interactive teaching, solving examples, discussion |
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16/17 |
Final exam |
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written exam |
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Required Course Resources |
| Resource Type | Resource Name |
| Recommended Course Material(s) |
 Radiation science for technologist, Stewart Carlyle Bushong, Elsevier, 2013
Essentials of radiation biology and protection, Steve Forshier, Delmar GEGAGR Lerning, USA, 2002
Radiobiology for radiobiologist, Eric J Hall, mato J. Giaccia, Wolters Kluwer, Philadelphia, 2012
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| |
| Required Course Material(s) |
Lecture slides
Problems and exercise
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Assessment Methods and Assessment Criteria |
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Semester/Year Assessments |
Number |
Contribution Percentage |
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Mid-term Exams (Written, Oral, etc.) |
1 |
60 |
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Homeworks/Projects/Others |
4 |
40 |
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Total |
100 |
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Rate of Semester/Year Assessments to Success |
40 |
| |
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Final Assessments
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100 |
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Rate of Final Assessments to Success
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60 |
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Total |
100 |
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| Contribution of the Course to Key Learning Outcomes |
| # | Key Learning Outcome | Contribution* |
|
1 |
Lists and describes the functions of health organizations, explains how national and international health organizations are organized, and explains how to manage clinics. |
0 |
|
2 |
owns some of the features of the human biological sciences (anatomy, physiology, pathology, cellular and biomolecular structure, radiologic anatomy, and so on.) related to Medical Physics applications |
2 |
|
3 |
explains and discusses the ethical and legal issues in the field of health care profession (eg, research ethics, data protection, privacy, reputation, ethics management). |
0 |
|
4 |
explains the neccessary technical substructure for the qualified service in the future of Medical Physics. |
0 |
|
5 |
explains the national legislative frameworks, regulations, guidelines and codes of practice of the European Community on the subject of medical Phyics |
0 |
|
6 |
In order to explain the structure, function, the characteristics and the limitations, he/she uses the physical concepts, principles and theories in a detailed and quantitative way by covering the areas of medical physics. Also explains the use of medical devices in the field of medical physics. |
0 |
|
7 |
describes the properties of ionizing radiation (electromagnetic, electrons, ions, neutrons), and other physical agents (electrical energy, static electricity / magnetic fields, non-ionizing electromagnetic radiation, vibration, sound and ultrasound, laser) in a detailed and quantitive way. |
0 |
|
8 |
describes the useful and reverse effects of onizing radiation and different physical agents that have a link with medical devices by means of biological models in a numerical way and explains the factors affecting the magnitude of the biological effect. Explains the ways of manipulation to improve clinical outcomes. |
5 |
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9 |
explains deterministic / stochastic, early / late, teratogenic / genetic effects related to each physical agent |
4 |
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10 |
In order to review something in a systematic manner in the field of Medical Physics, he/she makes up a list of related literature in the fields of the General Physics, Medical Physics and Health physics. |
0 |
|
11 |
uses the general concepts, principles and theories of physics to sort out clinical problems of safety / risk management related to the clinical use of medical devices, and on ionization radiation. |
0 |
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12 |
uses the general concepts,principles and theories of physics to transfer new devices and related techniques to the clinical environment. |
0 |
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13 |
designs digital clinical and biomedical studies based on meticulous and rigorous statistical base. |
0 |
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14 |
Uses statistical packages for the analysis of clinical and biomedical data. |
0 |
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15 |
tells the use of dosimetries used in medical physics based on physical concepts, principles and theories. |
0 |
|
16 |
identifies the dosimetric quantities of patients in each clinical process, and describes the methods for the measurement of these features. |
5 |
|
17 |
describes and explains different dosimetric quantities that are used and explains the relationship between dosimetric quantities (energy flux, kerma, absorbed dose). |
0 |
|
18 |
explains the principles of biological monitoring and dosimetry. |
0 |
|
19 |
Understands the nature of the anatomical medical images. |
0 |
|
20 |
During the administration of ionizing radiation to the patient, he/she determines the method and designs different applications to improve this method. |
0 |
| * Contribution levels are between 0 (not) and 5 (maximum). |
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| Student Workload - ECTS |
| Works | Number | Time (Hour) | Total Workload (Hour) |
| Course Related Works |
|
Class Time (Exam weeks are excluded) |
14 |
3 |
42 |
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Out of Class Study (Preliminary Work, Practice) |
14 |
3 |
42 |
| Assesment Related Works |
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Homeworks, Projects, Others |
4 |
5 |
20 |
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Mid-term Exams (Written, Oral, etc.) |
1 |
2 |
2 |
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Final Exam |
1 |
2 |
2 |
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Total Workload: | 108 |
| Total Workload / 25 (h): | 4.32 |
| ECTS Credit: | 4 |
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