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| Course Description |
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| Course Name |
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Bone Marrow and Peripheral Blood Stem Cell Transplantation I |
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| Course Code |
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PH-530 |
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| Course Type |
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Optional |
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| Level of Course |
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Second Cycle |
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| Year of Study |
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1 |
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| Course Semester |
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Fall and Spring (16 Weeks) |
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| ECTS |
: |
5 |
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| Name of Lecturer(s) |
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Prof.Dr. YURDANUR KILINÇ
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| Learning Outcomes of the Course |
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A student learns the peripheral blood and bone marrow celll evaluations.
A student learns the techniques of the peripheral blood and bone marrow celll collection, seperation, and freezing and keeping
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| Mode of Delivery |
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Face-to-Face |
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| Prerequisites and Co-Prerequisites |
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None |
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| Recommended Optional Programme Components |
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None |
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| Aim(s) of Course |
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Completing the course of "peripheral and bone marrow stem cell transplantation", students will gain knowledge about the origin, develeopment and differentiation of stem cells , hierarchic distribution of working plan, the morphology of the cells and will be able to perform experimentation and application. They will also learn and perform bone marrow aspiration smear, staining -including special histochemical ones, and also prepare the sample for flow-cytometry. |
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| Course Contents |
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The organization of hematopoietic system, hemopoiezis, the origin and development and differentiation of blood cells, the anatomy of bone marrow, the preparation of patient for bone marrow , bone marrow aspiration and biopsy, the collection, seperation and freezing of the cells; the examination of bone marrow and blood cells. |
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| Language of Instruction |
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Turkish |
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| Work Place |
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The Seminar Halls of Pediatric Hematology, The Laboratories of Pediatric Hematology and Pediatric Bone Marrow Transplantation Unit. |
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Course Outline /Schedule (Weekly) Planned Learning Activities |
| Week | Subject | Student's Preliminary Work | Learning Activities and Teaching Methods |
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1 |
Structure of Bone marrow :stroma and medullary regions regulation of hemopoiesis
Practice and Laboratory Work |
Study the sources for the course, search the related literature |
Instruction, seminar, group discussion, brainstorming. |
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2 |
Blood values in intrauterine and popstnatal life.
Practice and Laboratory Work |
Study the sources for the course, search the related literature |
Instruction, seminar, group discussion, brainstorming. |
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3 |
Indications of Bone Marrow Transplantation
Practice and Laboratory Work |
Study the sources for the course, search the related literature |
Instruction, seminar, group discussion, brainstorming. |
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4 |
The Indications of peripheral Blood Stem Cell Transplantation
Practice and Laboratory Work |
Study the sources for the course, search the related literature |
Instruction, seminar, group discussion, brainstorming. |
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5 |
Venous access
Practice and Laboratory Work |
Study the sources for the course, search the related literature |
Instruction, seminar, group discussion, brainstorming. |
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6 |
Graft Versus Host Disease
Practice and Laboratory Work |
Study the sources for the course, search the related literature |
Instruction, seminar, group discussion, brainstorming. |
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7 |
Preparation of the patient:TBI and Chemotherapy Preparation Regimes
Practice and Laboratory .Work |
Study the sources for the course, search the related literature |
Instruction, seminar, group discussion, brainstorming. |
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8 |
Preparation of operation room:Collection of stem cells.
Practice and Laboratory Work |
Study the sources for the course, search the related literature |
Instruction, seminar, group discussion, brainstorming. |
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9 |
Count blood cells, processing , selection and freezing .
Practice and Laboratory Work |
Study the sources for the course, search the related literature |
Instruction, seminar, group discussion, brainstorming. |
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10 |
Completion of transplanting process:early phase complications
Practice and Laboratory Work |
Study the sources for the course, search the related literature |
Instruction, seminar, group discussion, brainstorming. |
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11 |
Practice and Laboratory Work |
Study the sources for the course, search the related literature |
Instruction, seminar, group discussion, brainstorming. |
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12 |
Late Complications aftere bone marrow transplantation
Practice and Laboratory Work |
Study the sources for the course, search the related literature |
Instruction, seminar, group discussion, brainstorming. |
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13 |
Practice and Laboratory Work |
Study the sources for the course, search the related literature |
Instruction, seminar, group discussion, brainstorming. |
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14 |
Seminar |
Study the sources for the course, search the related literature |
Instruction, seminar, group discussion, brainstorming. |
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15 |
Seminar |
Study the sources for the course, search the related literature |
Instruction, seminar, group discussion, brainstorming. |
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16/17 |
Final Examination |
Study the sources for the course, search the related literature |
Oral, Written and Applied exams |
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Required Course Resources |
| Resource Type | Resource Name |
| Recommended Course Material(s) |
 Wintrobe´s Clinical Hematology:Greer JP, Foerster J, Lukens JN, Rodgers GM, Paraskaras F, Glader B(eds), Vol 1 and 2, 11th ed, Lippincott Williams and Wilkins, Philadelphia, 2004
Hematopoietic Stem Cell transplantation:Apperley J, Carreras E, Gluckman E, Gratwohl A, Masszi T(eds), The European School of Hematology EBMT Handbook, 5t ed, Saint Louis, 2008.
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| Required Course Material(s) | |
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Assessment Methods and Assessment Criteria |
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Semester/Year Assessments |
Number |
Contribution Percentage |
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Mid-term Exams (Written, Oral, etc.) |
1 |
90 |
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Homeworks/Projects/Others |
2 |
10 |
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Total |
100 |
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Rate of Semester/Year Assessments to Success |
40 |
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Final Assessments
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100 |
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Rate of Final Assessments to Success
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60 |
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Total |
100 |
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| Contribution of the Course to Key Learning Outcomes |
| # | Key Learning Outcome | Contribution* |
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1 |
A student can perform laboratory techniques. |
5 |
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2 |
A student can communicate and create bonds with the patients. |
1 |
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3 |
A student can teach the bone marrow stromal and medullary componants which are basic components of hematology. |
4 |
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4 |
A student can describe the rules of basic hematology. |
4 |
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5 |
A student can become trained in the area of molecular changes in benign and malign hematological disorders. |
4 |
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6 |
A students acknowledges blood cells biologies, blood and blood components transfusion and stem cell transplantation procedures. |
4 |
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7 |
A student gets prepared for stem cell transplant, collection, seperation, freezing topics. |
5 |
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8 |
A student can explain the structure and functions of erythrocytes, leucocytes and platelets. |
4 |
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9 |
A student can work in a pediatric hematology laboratory. |
4 |
|
10 |
A student gets prepared for basic rules of gene therapy. |
4 |
|
11 |
A student can investigate the molecular basis of benign and malign hematological disorders. |
4 |
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12 |
A student can explain the physiopathologies and results of hemostasis and thrombosis. |
2 |
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13 |
A student becomes competent in the application areas of blood cells and components and bone marrow transplantation |
4 |
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14 |
A student can perform application of the laboratory techniques necessary for pediatric hematology. |
5 |
| * Contribution levels are between 0 (not) and 5 (maximum). |
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| Student Workload - ECTS |
| Works | Number | Time (Hour) | Total Workload (Hour) |
| Course Related Works |
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Class Time (Exam weeks are excluded) |
14 |
4 |
56 |
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Out of Class Study (Preliminary Work, Practice) |
14 |
1 |
14 |
| Assesment Related Works |
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Homeworks, Projects, Others |
2 |
20 |
40 |
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Mid-term Exams (Written, Oral, etc.) |
1 |
10 |
10 |
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Final Exam |
1 |
10 |
10 |
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Total Workload: | 130 |
| Total Workload / 25 (h): | 5.2 |
| ECTS Credit: | 5 |
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