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Course Description Course Name : Gene Transfer in Childhood Cancers Course Code : PEDO-530 Course Type : Optional Level of Course : Second Cycle Year of Study : 1 Course Semester : Spring (16 Weeks) ECTS : 5 Name of Lecturer(s) : InstructorDr. ATILBİŞGİN Learning Outcomes of the Course : Students learn the terminology and main points for Gene Therapy Students explore the mechanisms of gene therapy Students learn to develop a gene therapy modality for a disease Students learn the terminology and main points for cellular therapy Students review the latest insights and discussions on the clinical use of gene and cell therapy Mode of Delivery : Face-to-Face Prerequisites and Co-Prerequisites : None Recommended Optional Programme Components : None Aim(s) of Course : Students gain knowledge on therapeutic applications of gene transfer as a new treatment modality Course Contents : Introduction to gene therapy Gene transfer methods Disease Targets Clinical Use Language of Instruction : Turkish Work Place : Meeting Room and laboratories   Course Outline /Schedule (Weekly) Planned Learning Activities Week Subject Student's Preliminary Work Learning Activities and Teaching Methods 1 Introductıon To Gene Therapy Searching on relevant online sources Lecture and interactive discussion 2 Gene transfer methods - Transformation Reviewing relevant literature Lecture and interactive discussion 3 Gen Transfer methods - Transduction Reviewing relevant literature Lecture and interactive discussion 4 Gen Transfer methods - Transfection Reviewing relevant literature Lecture and interactive discussion 5 Types Of Gene Therapy - Somatic Gene Therapy Reviewing relevant literature Lecture and interactive discussion 6 Types Of Gene Therapy - Germ Line Gene Therapy Reviewing relevant literature Lecture and interactive discussion 7 Direct gene transfer / Physical methods Reviewing relevant literature Lecture and interactive discussion 8 Mid-term Exam Revision Written exam 9 Vectors In Gene Therapy - Viruses Reviewing relevant literature Lecture and interactive discussion 10 Choosing The Viral Vector, Its Design and Targeting The Disease Designing a project Presentation of projects and interactive discussion 11 Vectors In Gene Therapy - Non-viral Methods Reviewing relevant literature Lecture and interactive discussion 12 Cell Therapy Reviewing relevant literature Lecture and interactive discussion 13 Gene and Cell Therapy In Action Reviewing relevant literature Lecture and interactive discussion 14 Future Perspectives On Gene and Cell Therapy Preparing the oral presentation of the project Students´ presentations and interactive discussion 15 FDA Approved Cellular and Gene Therapy Products Reviewing relevant literature Lecture and interactive discussion 16/17 Final Exam General revision Written exam   Required Course Resources Resource Type Resource Name Recommended Course Material(s) Required Course Material(s)  www.genetherapyreview.com  European Society of Gene and Cell Therapy web page  American Society of Gene & Cell Therapy web page   Assessment Methods and Assessment Criteria Semester/Year Assessments Number Contribution Percentage     Mid-term Exams (Written, Oral, etc.) 8 50     Homeworks/Projects/Others 15 50 Total 100 Rate of Semester/Year Assessments to Success 40   Final Assessments 100 Rate of Final Assessments to Success 60 Total 100   Contribution of the Course to Key Learning Outcomes # Key Learning Outcome Contribution* 1 A student can explain the basic concepts and principles of bone marrow transplantation 2 2 A student can explain the basic principles of tumor immunology 4 3 A student can explain the basic principles of oncogenesis and its molecular basis 3 4 A student can explain the basic principles of pediatric oncology 1 5 A student can explain the basic principles of tumor biology 3 * Contribution levels are between 0 (not) and 5 (maximum).   Student Workload - ECTS Works Number Time (Hour) Total Workload (Hour) Course Related Works     Class Time (Exam weeks are excluded) 14 2 28     Out of Class Study (Preliminary Work, Practice) 10 2 20 Assesment Related Works     Homeworks, Projects, Others 15 3 45     Mid-term Exams (Written, Oral, etc.) 8 2 16     Final Exam 8 2 16 Total Workload: 125 Total Workload / 25 (h): 5 ECTS Credit: 5