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Course Description Course Name : Molecular Basis of Childhood Cancers Course Code : PEDO-522 Course Type : Compulsory Level of Course : Second Cycle Year of Study : 1 Course Semester : Fall (16 Weeks) ECTS : 4 Name of Lecturer(s) : Assoc.Prof.Dr. SERHANKÜPELİ Learning Outcomes of the Course : A student learns molecular basis of childhood cancers A student learns the "cancer stem cell" A student learns the relation between cancer and genetic disorders A student learns the mechanism of specific cancers A student understands carcinogenesis and the factors related to it A student learns about molecularly targeted therapies Mode of Delivery : Face-to-Face Prerequisites and Co-Prerequisites : None Recommended Optional Programme Components : None Aim(s) of Course : Students are introduced to the basic principles, molecular mechanisms related with molecular basis of childhood cancers and are given information about the occurence of cancer and molecular interactions of factors related with carcinogenesis. Course Contents : Background information, Cancer Stem Cells, Genetic Disorders, Malignant Cell proliferation, Tumor Suppressor Genes, Mechanisms of Specific Cancers, Molecularly Targeted Therapies Language of Instruction : Turkish Work Place : Classroom   Course Outline /Schedule (Weekly) Planned Learning Activities Week Subject Student's Preliminary Work Learning Activities and Teaching Methods 1 Introduction Reading of related book chapters and journal articles Visual presentation and interactive discussion 2 General Nature of Cancer Reading of related book chapters and journal articles Visual presentation and interactive discussion 3 Genetic Disorders Reading of related book chapters and journal articles Visual presentation and interactive discussion 4 Protooncogenes Reading of related book chapters and journal articles Visual presentation and interactive discussion 5 Molecular Changes in Leukemias Reading of related book chapters and journal articles Visual presentation and interactive discussion 6 Molecular Changes in Lymphomas and Solid Tumors Reading of related book chapters and journal articles Visual presentation and interactive discussion 7 Carcinogenesis Reading of related book chapters and journal articles Visual presentation and interactive discussion 8 Mid-Semester Exam Reviewing the lectures Written Exam 9 Tumor Suppressor Genes Reading of related book chapters and journal articles Visual presentation and interactive discussion 10 Malignant Cell Proliferation Reading of related book chapters and journal articles Visual presentation and interactive discussion 11 Cancer Stem Cells Reading of related book chapters and journal articles Visual presentation and interactive discussion 12 Mechanisms of Clonal Expansion Reading of related book chapters and journal articles Visual presentation and interactive discussion 13 Cell Cycle Reading of related book chapters and journal articles Visual presentation and interactive discussion 14 Activity of Telomerase and Lenght of Telomere Reading of related book chapters and journal articles Visual presentation and interactive discussion 15 Molecularly Targeted Therapies Reading of related book chapters and journal articles Visual presentation and interactive discussion 16/17 Final Exam Reviewing all lectures Written Exam   Required Course Resources Resource Type Resource Name Recommended Course Material(s)  Pizzo PA, Poplack DG (editors). Principles and Practice of Pediatric Oncology. LWW, PA, 2011. Required Course Material(s)   Assessment Methods and Assessment Criteria Semester/Year Assessments Number Contribution Percentage     Mid-term Exams (Written, Oral, etc.) 8 50     Homeworks/Projects/Others 15 50 Total 100 Rate of Semester/Year Assessments to Success 40   Final Assessments 100 Rate of Final Assessments to Success 60 Total 100   Contribution of the Course to Key Learning Outcomes # Key Learning Outcome Contribution* 1 A student can explain the basic concepts and principles of bone marrow transplantation 1 2 A student can explain the basic principles of tumor immunology 2 3 A student can explain the basic principles of oncogenesis and its molecular basis 5 4 A student can explain the basic principles of pediatric oncology 4 5 A student can explain the basic principles of tumor biology 3 * Contribution levels are between 0 (not) and 5 (maximum).   Student Workload - ECTS Works Number Time (Hour) Total Workload (Hour) Course Related Works     Class Time (Exam weeks are excluded) 14 2 28     Out of Class Study (Preliminary Work, Practice) 10 2 20 Assesment Related Works     Homeworks, Projects, Others 15 2 30     Mid-term Exams (Written, Oral, etc.) 8 2 16     Final Exam 8 2 16 Total Workload: 110 Total Workload / 25 (h): 4.4 ECTS Credit: 4