| Course Description |
|
| Course Name |
: |
Antibodies |
|
| Course Code |
: |
TİM-504 |
|
| Course Type |
: |
Optional |
|
| Level of Course |
: |
Second Cycle |
|
| Year of Study |
: |
1 |
|
| Course Semester |
: |
Fall and Spring (16 Weeks) |
|
| ECTS |
: |
4 |
|
| Name of Lecturer(s) |
: |
Prof.Dr. AKGÜN YAMAN
|
|
| Learning Outcomes of the Course |
: |
Defines the structure of immunoglobulins and specifies the characteristics of immunoglubilin classes .
Describes the structure and function of IgG molecule and explains the relationship between IgG and the other antibody classes .
Is able to discern Fab and Fc sections, antibody binding region and hinge region.
Explains the relationship between the antibody and complement .
Describes the structure of human Fc receptors .
Defines the terms of somatic recombination .
Explains light and heavy chains of immunoglobulin and V,D,J recombinations .
Clarifies recombination signal sequence and the 12/23 rule .
Defines the relationship between gene conversion and immunoglobuline diversity .
Explains the mechanism of class-switching recombination.
|
|
| Mode of Delivery |
: |
Face-to-Face |
|
| Prerequisites and Co-Prerequisites |
: |
TİM-501 Basic Immunology
|
|
| Recommended Optional Programme Components |
: |
None |
|
| Aim(s) of Course |
: |
The aim of this lesson isto get information about the structure and functions of immunoglobulins and roles of immunogloblins in defence. |
|
| Course Contents |
: |
In this lesson, immunoglobulin classes are analyzed in structural and functional aspects, differences between classes and reasons of this are explained by genetics mechanisms, and the roles of immunoglobulins in defence system are discussed.
|
|
| Language of Instruction |
: |
Turkish |
|
| Work Place |
: |
C.U Faculty of Medicine Department of Medical Microbiology meeting room |
|
|
Course Outline /Schedule (Weekly) Planned Learning Activities |
| Week | Subject | Student's Preliminary Work | Learning Activities and Teaching Methods |
|
1 |
The structure of immunoglobulins |
Reading resources and lecture notes on the subject |
verbal lecture,presentation |
|
2 |
Functions of Immunoglobulins classes |
Reading resources and lecture notes on the subject |
verbal lecture |
|
3 |
The IgG molecule |
Reading resources and lecture notes on the subject |
verbal lecture,presentation |
|
4 |
The structure of Fab and Fc parts and Antibody binding region |
Reading resources and lecture notes on the subject |
verbal lecture,presentation |
|
5 |
Hinge region and subclasses of IgG |
Reading resources and lecture notes on the subject |
verbal lecture,presentation |
|
6 |
Antibodies and complement |
Reading resources and lecture notes on the subject |
verbal lecture |
|
7 |
Antibodies and human leukocyte Fc receptors |
Reading resources and lecture notes on the subject, article research |
verbal lecture,tartışma |
|
8 |
Midterm exam |
Exam preperation |
written exam |
|
9 |
The genetics and functions of antibody diversity |
Reading resources and lecture notes on the subject |
verbal lecture, discussion |
|
10 |
Variable gene segments and loci of immunoglobulins. |
Reading resources and lecture notes on the subject |
verbal lecture,presentation |
|
11 |
Recombination signal sequences |
Reading resources and lecture notes on the subject |
verbal lecture,presentation |
|
12 |
The mechanism of recombinase |
Reading resources and lecture notes on the subject |
verbal lecture,presentation |
|
13 |
Gene conversion and repertory diversity |
Reading resources and lecture notes on the subject |
verbal lecture |
|
14 |
Class-switch recombinations |
Reading resources and lecture notes on the subject |
verbal lecture |
|
15 |
Evoluation of the academic term |
none |
Discussion |
|
16/17 |
Final exam |
Exam preperation |
Written exam |
|
|
|
Required Course Resources |
| Resource Type | Resource Name |
| Recommended Course Material(s) |
 Delves PJ, Martin SJ, Burton DR, Roitt IM, Translation editor: Ilıman MN, Assistant editor: Yıldız M, Basic Immunolgy. Atlas Booktrade. 2008.
Levinson W, Jawetz E, Translation editor: Özgünen T, Medical microbiology and Immunology. Güneş Booktrade.
Male D, Brostoff J, Roth DB, Roitt I, Immunology. seventh edition
|
| |
| Required Course Material(s) | |
|
|
| Contribution of the Course to Key Learning Outcomes |
| # | Key Learning Outcome | Contribution* |
|
1 |
Identifies morphological and physiological characteristics of microorganisms |
2 |
|
2 |
Identificates genomic structures of microorganisms |
2 |
|
3 |
Explains microorganisms virulance factors and infection mechanisms. |
2 |
|
4 |
Defines the mechanisms of immune response and defense against microorganisms |
5 |
|
5 |
Lists the antimicrobial agents. |
2 |
|
6 |
Defines the mechanisms of resistance development against antimicrobial agents. |
2 |
|
7 |
Lists the microscopy, culture, serological and molecular diagnostic principles used in the laboratory diagnosis of infectious microorganisms. |
1 |
|
8 |
Lists microbiological tests for identification of microorganisms |
0 |
|
9 |
Implements and applies the methods used in the period from receipt of the clinical specimens up to identification of the causative agent . |
3 |
|
10 |
Prepares a suitable media, applicates the staining methods, biochemical tests and molecular diagnostic methods to identify microorganisms from clinical samples. |
1 |
|
11 |
Applies the biochemical tests and basic microbiological staining methods which are necessary for microbiological identification . |
1 |
|
12 |
Determines the microorganisms by using basic molecular diagnostic techniques. |
1 |
|
13 |
Works individually or as a team member related to the field. |
4 |
|
14 |
Carries out the missions given within the scope of research projects. |
4 |
|
15 |
Develops a positive attitude and behaviour towards lifelong learning. |
5 |
|
16 |
Evaluates own knowledge and new-learned knowledge in a critical view after graduating. |
5 |
|
17 |
Communicates effectively. |
5 |
|
18 |
Transfers their own ideas and developments in the field, and offers solutions visually and verbally supporting with qualitative and quantitative data. |
3 |
|
19 |
Applies ethical principles during study, evaluation and result sharing. |
5 |
| * Contribution levels are between 0 (not) and 5 (maximum). |
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