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Course Description Course Name : Pharmacogenetics Course Code : FAR523 Course Type : Optional Level of Course : Second Cycle Year of Study : 1 Course Semester : Fall and Spring (16 Weeks) ECTS : 4 Name of Lecturer(s) : Assoc.Prof.Dr. MEHMET ATA SEÇİLMİŞ Learning Outcomes of the Course : Considers the involvement of genetic and environmental factors in different responses to drugs between individuals Knows about the polymorphism of various enzymes that activate and inactivate drugs by biotransformation Knows the role of genetic factors on pharmacokinetics and pharmacodinamics Knows the effect of genetic polymorphism on the enzyme induction or inhibition Knows the role of genetic polymorphism on differences in response to drug therapy Mode of Delivery : Face-to-Face Prerequisites and Co-Prerequisites : None Recommended Optional Programme Components : None Aim(s) of Course : It is known that drug responses reveal differences among individuals in terms of both therapeutic and adverse effects due to the differences in metabolic pathways. The purpose of the lesson is to correlate this difference with genetic structure of the patient. Course Contents : The role of pharmacogenetics on drug response variability Genomic basis of pharmacogenetics, Ethnic and race-specific polymorphisms, Pharmacogenetics studies. Language of Instruction : Turkish Work Place : Classroom   Course Outline /Schedule (Weekly) Planned Learning Activities Week Subject Student's Preliminary Work Learning Activities and Teaching Methods 1 To consider the involvement of genetic and environmental factors in different responses to drugs between individuals textbook reading and literature review Presentation, discussion, question-answer 2 The investigation of polymorphism of enzyms that play a role on drug biotransformation textbook reading and literature review Presentation, discussion, question-answer 3 The investigation of polymorphism of enzyms that play a role on drug biotransformation textbook reading and literature review Presentation, discussion, question-answer 4 The factors affecting the drug metabolism: Genetic polymorphism and environmental factors textbook reading and literature review Presentation, discussion, question-answer 5 The differences in drug pharmacokinetics due to genetic factors textbook reading and literature review Presentation, discussion, question-answer 6 The differences in drug pharmacokinetics due to genetic factors textbook reading and literature review Presentation, discussion, question-answer 7 The differences in drug pharmacodinamics due to genetic polymorphism textbook reading and literature review Presentation, discussion, question-answer 8 Midterm revision of previous studies Oral exam 9 The effect of genetic polymorphism on the trend of enzyme induction or inhibition due to environmental factors and nutrition textbook reading and literature review Presentation, discussion, question-answer 10 The effect of genetic polymorphism on the trend of enzyme induction or inhibition due to environmental factors and nutrition textbook reading and literature review Presentation, discussion, question-answer 11 The importance of pharmacogenetics in personalized therapy textbook reading and literature review Presentation, discussion, question-answer 12 Tamoxifen treatment and its significance in terms of CYP2D6 polymorphism textbook reading and literature review Presentation, discussion, question-answer 13 Clopidogrel treatment and its significance in terms of CYP2C19 polymorphism textbook reading and literature review Presentation, discussion, question-answer 14 Review of literature, oral presentations and discussions textbook reading and literature review Presentation, discussion, question-answer 15 Review of literature, oral presentation and discussions textbook reading and literature review Presentation, discussion, question-answer 16/17 Final exam revision of previous studies Oral exam   Required Course Resources Resource Type Resource Name Recommended Course Material(s)  Basic and Clinical Pharmacology, Katzung  The Pharmacological Basis of Therapeutics (Goodman&Gillman)     Required Course Material(s)  Internet and library databases   Assessment Methods and Assessment Criteria Semester/Year Assessments Number Contribution Percentage     Mid-term Exams (Written, Oral, etc.) 1 60     Homeworks/Projects/Others 3 40 Total 100 Rate of Semester/Year Assessments to Success 40   Final Assessments 100 Rate of Final Assessments to Success 60 Total 100   Contribution of the Course to Key Learning Outcomes # Key Learning Outcome Contribution* 1 Students gain the ability to research on the areas like preventing irrational drug use detecting the problems due to drug use 5 2 Students gain basic pharmacological information 5 3 Students have the ability to take on the responsibilities of pharmacology 5 4 Students know the experimental research techniques in pharmacology 5 5 Students gain the ability to present their knowledge in an academic environment 5 6 Students have an ability to access scientific information 5 7 Students are informed about pharmacovigilance 5 8 Students have the ability to apply the basic principles of rational drug use on daily practice 5 9 Students gain the ability to take place in the in vitro/ in vivo animal experiments 0 10 Students gain the ability to plan and conduct experimental pharmacological projects and analyze the experimental results. 0 11 Students gain the ability to follow present literature in the field of pharmacology 5 12 Students guide the assistant health personnel to receive pharmacology education 0 13 Students are informed about rational drug use 5 14 Students know the pharmacological research areas 5 * Contribution levels are between 0 (not) and 5 (maximum).   Student Workload - ECTS Works Number Time (Hour) Total Workload (Hour) Course Related Works     Class Time (Exam weeks are excluded) 14 2 28     Out of Class Study (Preliminary Work, Practice) 14 2 28 Assesment Related Works     Homeworks, Projects, Others 3 10 30     Mid-term Exams (Written, Oral, etc.) 1 10 10     Final Exam 1 10 10 Total Workload: 106 Total Workload / 25 (h): 4.24 ECTS Credit: 4