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Course Description Course Name : Cytogenetics Course Code : BİO525 Course Type : Compulsory Level of Course : Second Cycle Year of Study : 1 Course Semester : Spring (16 Weeks) ECTS : 6 Name of Lecturer(s) : Prof.Dr. OSMAN DEMİRHAN Learning Outcomes of the Course : Knows the structure and formation of chromosome. Recognises each human chromosome independently. Knows numerical chromosomal syndromes. Knows structural chromosomal syndromes. Knows all the steps in the formation of chromosome preparation. Is able to analyze the chromosomes under the microscope. Mode of Delivery : Face-to-Face Prerequisites and Co-Prerequisites : BİO501 Principles of Medical Biology Recommended Optional Programme Components : None Aim(s) of Course : To give detailed information about the methods of teaching and application of the basic principles of cytogenetics. Course Contents : Chromosomes structure, function, phenotypic effects, theoretical and practical applications of the methods of chromosome synthesis. Language of Instruction : Turkish Work Place : Department of Medical Biology and Genetics and genetic laboratories, seminar room   Course Outline /Schedule (Weekly) Planned Learning Activities Week Subject Student's Preliminary Work Learning Activities and Teaching Methods 1 Genetics and the historical background of cytogenetics Listening and interpretation, observation, critical thinking, question development Standart classroom technologies, multimedia devices, projector, computer 2 The formation of chromosome Listening and interpretation, observation, critical thinking, question development Standart classroom technologies, multimedia devices, projector, computer 3 Structural features of chromosomes Listening and interpretation, observation, critical thinking, question development Standart classroom technologies, multimedia devices, projector, computer 4 Methods of obtaining chromosomes Listening and interpretation, observation, critical thinking, question development Standart classroom technologies, multimedia devices, projector, computer 5 Practises of culture and preparation related to obtaining chromosomes Listening and interpretation, observation, critical thinking, question development Standart classroom technologies, multimedia devices, projector, computer 6 Practises of culture and preparation related to obtaining chromosomes Listening and interpretation, observation, critical thinking, question development Standart classroom technologies, multimedia devices, projector, computer 7 Chromosome coloring and banding methods Listening and interpretation, observation, critical thinking, question development Standart classroom technologies, multimedia devices, projector, computer 8 Midterm exam Preparing multiple-choice questions Written exam 9 Recognition and classification of chromosomes Listening and interpretation, observation, critical thinking, question development Standart classroom technologies, multimedia devices, projector, computer 10 Recognition and classification of chromosomes Listening and interpretation, observation, critical thinking, question development Standart classroom technologies, multimedia devices, projector, computer 11 Microscopic examination of chromosomes Listening and interpretation, observation, critical thinking, question development Standart classroom technologies, multimedia devices, projector, computer 12 Microscopic examination of chromosomes Listening and interpretation, observation, critical thinking, question development Standart classroom technologies, multimedia devices, projector, computer 13 Analyses of the abnormal chromosome Listening and interpretation, observation, critical thinking, question development Standart classroom technologies, multimedia devices, projector, computer 14 Numerical chromosome aberrations Listening and interpretation, observation, critical thinking, question development Standart classroom technologies, multimedia devices, projector, computer 15 Structural chromosome aberrations Listening and interpretation, observation, critical thinking, question development Standart classroom technologies, multimedia devices, projector, computer 16/17 Final exam Preparing multiple-choice questions Written exam and discussion in the form of questions and answers   Required Course Resources Resource Type Resource Name Recommended Course Material(s)  Steven L. Gersen and Martha B. Keagle. The Principles of Clinical Cytogenetcs, 2005  Başaran N. Medical Genetics. Bilim Teknik Yayınevi, Sixth Edition, Çağaloğlu, İstanbul, 1996.  Kasap H, Kasap M, Demirhan O, Alptekin D, Lüleyap Ü, Pazarbaşı A, Güzel Aİ. Medical Biology and Genetics. Editör Halil Kasap, Nobel Tıp Kitabevi, Adana, 2010. Required Course Material(s)   Assessment Methods and Assessment Criteria Semester/Year Assessments Number Contribution Percentage     Mid-term Exams (Written, Oral, etc.) 1 60     Homeworks/Projects/Others 5 40 Total 100 Rate of Semester/Year Assessments to Success 40   Final Assessments 100 Rate of Final Assessments to Success 60 Total 100   Contribution of the Course to Key Learning Outcomes # Key Learning Outcome Contribution* 1 Explains theorical debates of three main areas (philosophy, sociology, psychology) in relation to today´s problems 0 2 Knows the functions of tissues and organ systems. 0 3 Knows the structure of the genetic material. 4 4 Knows the genetic diseases and the genes that cause genetic diseases and disorders. 4 5 Is able to conduct molecular and cytogenetic diagnosis analysis. 5 6 Knows what numerical and structural abnormalities of the autosomes and the sex chromosomes mean and explain them. 5 7 Is able to do DNA isolation from all types of tissue. 2 8 Is able to perform PCR. 2 9 Is able to perform and interpret agarose and polyacrylamide gel electrophoresis. 3 10 Is able to measure the DNA obtained from tissues using a spectrophotometer. 0 11 Is capable of interpreting and implementing QF-PCR technique. 2 12 Is able to cell culture from blood, amniotic, chorionic villus biopsy specimens, and obtain chromosome preparation. 5 13 Is able to recognize and interpret all human chromosomes from the preparations derived from chromosome karyotype analysis. 5 14 Learns how to write and comment on a scientific article. 5 15 Knows the structure of genes. 3 16 Knows the chromosome and gene mutations. 5 17 Knows patterns of inheritance (autosomal dominant, autosomal recessive, sex-linked dominant and recessive inheritance models). 5 * Contribution levels are between 0 (not) and 5 (maximum).   Student Workload - ECTS Works Number Time (Hour) Total Workload (Hour) Course Related Works     Class Time (Exam weeks are excluded) 14 4 56     Out of Class Study (Preliminary Work, Practice) 14 5 70 Assesment Related Works     Homeworks, Projects, Others 5 4 20     Mid-term Exams (Written, Oral, etc.) 1 1 1     Final Exam 1 1 1 Total Workload: 148 Total Workload / 25 (h): 5.92 ECTS Credit: 6